联用曲美他嗪和不同剂量左卡尼汀治疗心力衰竭疗效观察  

作　　者：崇爱国[1] 季红慧[1] 钟泽[1] 吴新东[1] 张伟伟[1] 罗秀英[1] 

机构地区：[1]浙江大学医学院附属第二医院建德分院,311600

出　　处：《浙江临床医学》2020年第8期1116-1117,共2页Zhejiang Clinical Medical Journal

基　　金：杭州市科技计划引导项目(20163501Y159)。

摘　　要：目的 比较曲美他嗪联合不同剂量左卡尼汀治疗慢性心衰的疗效.方法 选取2016年8月至2018年9月住院治疗的250例慢性心衰患者,所有患者均接受常规抗心衰药物及曲美他嗪治疗,在此基础上按随机原则分为对照组、观察组1、观察组2、观察组3、观察组4,观察组给予不同剂量左卡尼汀,14d后比较各组患者6min步行距离、左心室射血分数和N端脑钠肽水平.结果 治疗14d后,观察组2患者的6min步行距离较其它观察组增加(P<0.05),观察组2左心室射血分数同对照组和观察组1比较改善不明显(P>0.05),但明显好于观察组3和观察组4,而N端脑钠肽则在观察组1和观察组2下降比其他观察组更明显(P<0.05).结论 常规药物及曲美他嗪治疗基础上,加用小剂量左卡尼汀可改善患者心功能,但随着左卡尼汀剂量增大,患者心功能并不能进一步改善.Objective To compared the trimetazidine combined with different doses of L-carnitine in the treatment of chronic heart failure.Methods 250 parients with chronic heart failure who were hospitalized in our hospital from August 2016 to September 2018 were selected.All patients were treated with conventional anti-heart failure drugs and trimetazidine.On this basis,they were randomly divided into control group and observation group 1,observation group 2,observation group 3,observation group 4,the observarion group were given with different doses of L-carnitine.14 days later,each group of patients compared 6 minutes walking distance,left ventricular ejection fraction and N-tenninal brain natriuretic peptide levels.Results After 14 days of treatment,the 6-minute walking distance of patients in observation group 2 increased compared with other observation groups(P<0.05).The left ventricular ejection fraction of observation group 2 was not significantly improved compared with that of control group and observation group 1(P>0.05),but it was significantly better than that of observation group 3 and observation group 4,while the N-terminal brain natriuretic peptide decreased in the observation group 1 and the observation group 2 more obviously than other observation groups(P<0.05).Conclusion On the basis of conventional medicine and trimetazidine treatment,low dose of L-camitine can iniprove the heart fiinction of patients,but with the increase of L-camitine dose,the heart function of patients can not be further improved.

关 键 词：心力衰竭 心功能 左卡尼汀 曲美他嗪 

分 类 号：R54[医药卫生—心血管疾病]