高尿酸血症对老年原发性高血压患者动脉僵硬度的影响  

作　　者：刘燕[1] 孙悦 施胜铭[1] 

机构地区：[1]浙江省湖州市第一人民医院,313000

出　　处：《浙江临床医学》2020年第8期1171-1172,1175,共3页Zhejiang Clinical Medical Journal

摘　　要：目的 探讨高尿酸血症(HUA)对老年原发性高血压患者动脉僵硬度的影响.方法 选择老年原发性高血压患者155例(高血压组),其中HUA 80例,非HUA 75例;同期选择无高血压病史老年健康体检者150例(对照组),其中HUA 30例,非HUA 120例.测定两组患者血脂、空腹血糖、肌酐、超敏C反应蛋白(HsCRP)、尿酸及肱-踝脉搏波传导速度(BaPWV).结果 高血压组尿酸、HsCRP和BaPWV水平显著高于对照组,高血压HUA组患者尿酸、HsCRP和BaPWV水平显著高于高血压非HUA患者,所有受试者、高血压组、对照组血浆尿酸水平均与BaPWV呈正相关.多重线性回归分析显示,血浆尿酸水平是BaPWV的独立危险因素.结论 伴HUA的老年原发性高血压患者动脉僵硬度更高,可能与炎症反应等机制有关,尿酸是BaPWV的独立危险因素.Objective To explore the effect of hyperuricemia(HUA)on arterial stiffness in elderly patients with essential hypertension.Methods 155 elderly patients with essential hypertension served as hypertension group were selected,including 80 cases of HUA and 75 cases of non-HUA.Meanwhile,150 elderly health checkups without hypertension history served as control group were selected,including 30 cases of HUA and 120 cases of non-HUA.Blood lipid,fasting blood glucose,creatinine,hypersensitive C-reactive protein(HsCRP),uric acid and Brachial ankle pulse wave conduction velocity(BaPWV)were measured.Results The levels of uric acid,HsCRP and BaPWV in hypertension group were significantly higher than those in control group(P<0.05).The levels of uric acid,HsCRP and baPWV were significantly higher in hypertension patients with HUA than in hypertension patients with non-HUA(P<0.05).The uric acid level was related with the BaPWV in all subjects,hypertension group and control group.Multiple linear regression analysis showed that the uric acid level was an independent risk factor for BaPWV.Conclusion The arterial stiffness of elderly essential hypertension patients with HUA is higher,which may be related to inflammatory response.Uric acid is an independent risk factor for baPWV.

关 键 词：高尿酸血症 动脉僵硬度 脉搏波传导速度 高血压 

分 类 号：R54[医药卫生—心血管疾病]