肾康针栓联合治疗气虚湿浊瘀阻型慢性肾脏病3-5期的临床研究  

Clinical Study of Shenkang Injection Combined with Shenkang Suppository in Treating Chronic Kidney Disease Stage 3-5 with Qi Deficiency,Dampness,Turbidity and Stagnation

作　　者：远方[1] 赵万超 李岩[1] 王东梅[1] 许烨[1] 梁亮 修静 刘烨[1] 杨刚 李志明[1] 郭玲[1] 于艳[1] YUAN Fang;ZHAO Wanchao;LI Yan;WANG Dongmei;XU Ye;LIANG Liang;XIU Jing;LIU Ye;YANG Gang;LI Zhiming;GUO Ling;YU Yan(Affiliated Hospital of Liaoning University of TCM,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医杂志》2020年第6期92-95,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：辽宁省自然科学基金(20170540607)。

摘　　要：目的观察肾康注射液联合肾康栓治疗慢性肾脏病3~5期的临床疗效。方法选取近一年于该院住院的85例慢性肾脏病3-5期患者,随机分成治疗组44例和对照组41例,两组患者的病程及性别、年龄等差异无统计学意义,具有可比性(P>0.05)。均采用低优质蛋白、低盐、低磷、低钾饮食,控制血压、纠正离子紊乱、改善贫血等对症治疗。治疗组:予肾康注射液60 mL加入5%葡萄糖或0.9%氯化钠注射液200 mL中缓慢静注,每日1次,联合肾康栓6 g日2次肛门纳入给药,连续治疗15 d。对照组:仅予肾康注射液60 mL加入5%葡萄糖或0.9%氯化钠注射液200 mL中缓慢静注,每日1次,连续治疗15 d。观察患者治疗前后血清肌酐、尿素氮、肌酐清除率等指标以及中医证候积分方面的变化规律。结果 (1)疾病疗效:治疗组显效率和总有效率分别为8例(18.18%)和39例(88.64%),对照组显效率和总有效率分别为10例(24.39%)和34例(82.93%),两组比较差异无统计学意义(P>0.05),但治疗组有效率比例仍优于对照组。(2)中医证候疗效:治疗组显效率和总有效率分别为19例(43.18%) 40例(90.91%),对照组显效率和总有效率分别为14例(34.15%)和32例(78.05%),两组比较差异有统计学意义(P<0.05)。(3)检测指标比较:治疗组治疗后血清肌酐、尿素氮均低于治疗前;治疗组治疗后肌酐清除率较本组治疗前明显上升(P<0.05)。对照组组内比较有统计学意义(P<0.05)。(4)症状积分比较:治疗组治疗后中医症状积分较本组治疗前明显降低(P<0.05)。对照组组内比较有统计学意义(P<0.05)。两组血肌酐、尿素氮、中医证候积分在治疗后组间比较差异均有统计学意义(P<0.05),肌酐清除率在治疗后组间比较差异有统计学意义(P<0.05)。结论肾康注射液联合肾康栓治疗组,在改善症状积分、肾功能方面优于单用肾康注射液对照组。肾康针栓联合互为补充,局部与整体调治,益气活血,通腑Objective To observe the clinical effect of Shenkang Injection combined with Shenkang Suppository on CKD3-5.Methods Eighty-five patients with CKD3-5 hospitalized in our hospital in the past year were randomly divided into treatment group(44 cases) and control group(41 cases).The course of disease,gender and age of the two groups had no statistical difference and were comparable(P>0.05).All patients were given low-quality protein,low salt,low phosphorus,low potassium diet,blood pressure control,ion disorder correcting,improving anemia and other symptomatic treatment.The treatment group: 60 mL of Shenkang Injection was slowly injected intravenously into 200 mL of 5% glucose or 0.9% sodium chloride injection,once a day,and 6 g of Shenkang Suppository was injected into anus twice a day for continuous treatment for 15 days.Control group: Only 60 mL of Shenkang Injection was added with 200 mL of 5% glucose or 0.9% sodium chloride injection for slow intravenous injection once a day for 15 consecutive days.The changes of serum creatinine,urea nitrogen,creatinine clearance rate and TCM syndrome scores before and after treatment were observed.Results(1) Disease curative effect: The effective rate and total effective rate in the treatment group were 18.18%(8 cases) and 88.64%(39 cases),respectively.The effective rate and total effective rate in the control group were 24.39%(10 cases) and 82.93%(34 cases),respectively.There was no significant difference between the two groups(P>0.05),but the effective rate in the treatment group was still better than that in the control group.(2) TCM syndrome curative effect: The obvious and total effective rates in the treatment group were 43.18%(19 cases) and 90.91%(40 cases) respectively,while the obvious and total effective rates in the control group were 34.15%(14 cases) and 78.05%(32 cases),respectively.The difference between the two groups was statistically significant(P<0.05).(3) Comparison of detection indexes: Scr and BUN in treatment group were lower than those before treatment.EG

关 键 词：慢性肾脏病 气虚湿浊瘀阻 肾康注射液 肾康栓 

分 类 号：R692[医药卫生—泌尿科学]