慢性乙型肝炎病毒感染者肝组织病理变化与四种中医证素相关性的前瞻性研究  

Prospective Study on Correlation Between Pathological Changes of Liver Tissue and Four TCM Syndromes in Patients with Chronic HBV Infection

作　　者：谷莉莉 王宪波[2] GU Lili;WANG Xianbo(Beijing Bo'ai Hospital,China Rehabilitation Research Center,Beijing 100068,China;Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]中国康复研究中心北京博爱医院,北京100068 [2]首都医科大学北京地坛医院,北京100015

出　　处：《辽宁中医杂志》2020年第6期127-130,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探讨慢性乙型肝炎病毒(HBV)感染者肝组织病理学变化与湿、热、瘀、虚四种证候要素的相关性。方法前瞻性研究324例慢性HBV感染者的临床资料,并辨别其所属证候要素,分析湿、热、瘀、虚与病理学结果显示≥G2、≥S2、≥G2S2的关系。结果证候要素以湿或热为主的患者肝脏病理一般无显著性肝脏炎症[所占比例分别为79.35%(73/92),81.36%(48/59)],和无显著性肝纤维化[所占比例分别为83.70%(77/92),84.75%(50/59)];证候要素瘀和虚与湿、热在肝脏炎症和纤维化方面比较,差异有统计学意义(均P<0.05)。结论以瘀或虚为主要证候要素慢性HBV感染者,肝脏炎症和纤维化较湿或热为主要证候要素者严重。Objective To investigate the correlation of liver histopathological changes and dampness,heat,blood stasis and deficiency these four syndrome factors in patients with chronic HBV infection.Methods The prospective studies were used to research 324 patients’ clinical data and distinguish syndrome factors,analyzing the relationship between these four main syndrome factors and pathology results≥G2,≥S2 or ≥G2S2.Results The patients with dampness or heat had no significant liver inflammation[79.35%(73/92),81.36%(48/59) ] and no significant fibrosis[83.70%(77/92),84.75%(50/59) ].The syndrome factors blood stasis and deficiency compared with dampness or heat,the differences was statically significant(P<0.05).Conclusion Patients with blood stasis and deficiency have serious liver histopathological changes than those with dampness and heat.

关 键 词：慢性HBV感染 病理学变化 证候要素 

分 类 号：R512.62[医药卫生—内科学]