低FODMAP饮食联合美沙拉嗪在溃疡性结肠炎患者治疗中的应用  

Application of Low FODMAP Diet Combined Mesalazine in the Treatment of Patients with Ulcerative Colitis

作　　者：章小艳 束龙[1] 王卫光[1] 童晓清[1] 周锋[2] 郑培奋[2] Zhang Xiaoyan;Shu Long;Wang Weiguang(Department of Nutrition and Gastroenterology,Zhejiang Hospital,Zhejiang 310013,China)

机构地区：[1]浙江医院临床营养科,杭州310013 [2]浙江医院消化内科,杭州310013

出　　处：《医学研究杂志》2020年第8期109-112,共4页Journal of Medical Research

基　　金：浙江省自然科学基金资助项目(LY17H030008);浙江省卫生厅一般项目(2017KY190);浙江省中医药科研基金资助项目(2020ZB009)。

摘　　要：目的探讨低FODMAP饮食联合美沙拉嗪对轻中度溃疡性结肠炎(UC)患者的疗效影响,为该病的饮食干预治疗提供依据。方法选取2018年10月~2020年2月在浙江医院消化内科就诊的轻中度活动性UC患者为研究对象,按照数字表法随机分为实验组(低FODMAP饮食+美沙拉嗪口服)和对照组(普通饮食+美沙拉嗪口服)。两组患者均临床治疗6周,随访6周,每周观察UC患者症状变化及治疗效果。结果临床干预期间,实验组患者排便次数、Mayo评分、炎性指标均明显低于对照组,且差异有统计学意义(P<0.01);随访期间两组患者之间的差异逐渐减小,差异无统计学意义(P>0.05)。结论低FODMAP饮食联合美沙拉嗪能有效改善轻中度活动性UC患者的临床症状。Objective To explore the effect of low FODMAP diet combined with mesalazine on patients with mild to moderate ulcerative colitis(UC),and to provide basis for dietary intervention for this disease.Methods Patients with mild to moderately active UC who were treated in the Department of Gastroenterology of Zhejiang Hospital from October 2018 to February 2020 were selected as the research subjects.They were divided into experimental group(low FODMAP diet+mesalazine oral)and control group(ordinary diet+mesalazine oral)according to the random number table method.Patients in both groups were treated clinically for six weeks and followed up for six weeks.The symptoms and treatment effects of UC patients were observed every week.Results During the clinical intervention,the defecation frequency,mayo score,and inflammation indexes of the experimental group were significantly lower than those of the control group,and the differences were statistically significant(P<0.01).During the follow-up period,the differences between the two groups of patients gradually decreased,and the differences was not statistically significant(P>0.05).Conclusion Low FODMAP diet combined with mesalazine can effectively improve the clinical symptoms of patients with mild to moderate active UC.

关 键 词：低FODMAP饮食 美沙拉嗪 溃疡性结肠炎 轻中度 

分 类 号：R5[医药卫生—内科学]