急性冠状动脉综合征患者糖化血红蛋白与冠状动脉SYNTAX评分的相关性  

Correlation of the Serum Level of HbAlc with SYNTAX Score in Patients with Acute Coronary Syndrome

作　　者：穆利英[1] 吴昱[1] 孟帅 杜凤和[1] 郭彩霞[1] Mu Liying;Wu Yu;Meng Shuai(Department of Cardiology,Beijing Tian tan Hospital,Capital Medical University,Beijing 1001603 China)

机构地区：[1]首都医科大学附属北京天坛医院心脏及大血管中心,100160

出　　处：《医学研究杂志》2020年第8期128-132,共5页Journal of Medical Research

基　　金：中国中青年临床研究基金资助项目(2017-CCA-VG-045)。

摘　　要：目的探讨急性冠状动脉综合征(acute coronary syndrome,ACS)患者糖化血红蛋白(glycated hemoglobin,HbAlc)水平与冠状动脉病变SYNTAX评分的相关性、方法选取2019年1〜5月在笔者医院心脏中心重症监护病房住院的ACS患者108例,采用SYNTAX评分评定冠状动脉病变程度,分为两组,即冠状动脉轻度病变组(SYNTAX评分≤22,n=74)和中重度病变组(SYNTAX评分≥23,n=34),分别检测两组患者HbAlc水平,比较两组间HbAlc水平及其他临床资料,分析上述指标与SYNTAX评分的独立相关性。结果在ACS患者中,冠状动脉中重度病变组HbAlc水平明显高于轻度病变组(7.50%±2.17%vs 6.56%±1.34%,P=0.009),差异有统计学意义。Spearman相关分析结果显示,HbAlc水平与SYNTAX评分呈正相关(r=0.235,P<0.05)。多因素Logistic回归分析结果显示,HbAlc是ACS患者冠状动脉中重度病变的独立预测因子(OR=2.004,95%CI:1.063-3.777,P<0.05)。结论HbAlc水平与ACS患者的SYNTAX评分独立且显著相关,有助于判断冠状动脉狭窄病变的危险分层。Objective To analyze the correlation between glycated hemoglobin(HbAle)level and the severity of coronary artery lesions evaluated by SYNTAX score.Methods From January to May 2019,a total of 108 patients who underwent percutaneous coronary intervention after idenified acute coronary syndrome were enrolled.The serum HbAlc level of the patients was tested.According to the degree of coronary lesions evaluated by SYNTAX score,the patients were divided into low risk group(SYNTAX score≤22,n=74),intermediated-high risk group(SYNTAX score≥23,n=34).Correlation between HbA1c and SYNTAX score in patients with ACS were analyzed.Results The level of HbAle was higher in the intermediated-high risk group compared with the low risk group(7.50%±2.17%vs6.56%±1.34%,P=0.009).There was stalistically significant difference in HbAle between the two groups(P<0.05).Correlation analysis results showed that HbAle was positively correlated with SYNTAX score in patients with ACS(r=0.235.P<0.05).Multivariate logistic regression analysis results showed that HbAle was an independent predictor of intermediated-high SYNTAX score in patients with ACS(OR=2.004,95%C1:1.063-3.777,P<0.05),Conclusion HbAlc level was independent and significantly correlated with the SYNTAX score of ACS patients,which was helpful to judge the risk stratification of coronary stenosis.

关 键 词：急性冠状动脉综合征 糖化血红蛋白 SYNTAX评分 

分 类 号：R543.3[医药卫生—心血管疾病]