尿蛋白和肌酐的比值与绝经后2型糖尿病患者骨密度相关性研究  

Correlation between the ratio of urinary protein and creatinine and bone mineral density in postmenopausal patients with type 2 diabetes

作　　者：袁飞[1] 彭雯 赵焕苓 YUAN Fei;PENG Wen;ZHAO Huanling(Department of Rheumatology, Dongguan People’s Hospital, Dongguan 523000;Dongguan Health School, Dongguan 523000, China)

机构地区：[1]东莞市人民医院风湿科,广东东莞523000 [2]东莞卫生学校,广东东莞523000

出　　处：《中国骨质疏松杂志》2020年第8期1180-1184,共5页Chinese Journal of Osteoporosis

摘　　要：目的探讨绝经后2型糖尿病患者骨密度与尿蛋白/肌酐的比值的相关性。方法评估2016年1月至2018年7月来我院就诊的120例2型糖尿病绝经后妇女的情况。收集患者的一般临床和生化指标并分析相关数据之间的相关性。结果120例绝经后2型糖尿病患者中,骨质疏松和骨质减少的患病率分别为34.2%(41例)和33.3%(40例)。多元回归分析研究发现年龄、体质量指数、CCr和腰椎骨密度之间显著相关(P<0.05);而股骨骨密度仅与年龄具有密切相关(P<0.05)。进一步研究发现与非蛋白尿患者相比,微量蛋白尿和大量蛋白尿[尿蛋白-肌酐比(UACR)≥30]的患者骨质疏松症发生率显著高于对照组(P<0.05)。结论本研究表明较高的UACR水平可能和绝经后2型糖尿病患者骨质疏松症风险增加相关。Objective To explore the correlation between bone mineral density and the ratio of urine protein and creatinine in postmenopausal patients with type 2 diabetes.Methods One hundred and twenty postmenopausal women with type 2 diabetes who visited our hospital from January 2016 to July 2018 were assessed.The general clinical and biochemical indexes of the patients were collected and the correlation between the relevant data was analyzed.Results Among 120 postmenopausal patients with type 2 diabetes,the incidences of osteoporosis and osteopenia were 34.2%(41 cases)and 33.3%(40 cases),respectively.Multiple regression analysis showed that age,BMI,and CCr,were significantly correlated with lumbar BMD(P<0.05).BMD of the femur was closely correlated with age only(P<0.05).Further study showed that the patients with microalbuminuria and macroalbuminuria[urine albumin-to-creatinine ratio(UACR)≥30]had a significantly higher incidence of osteoporosis than the subjects with non-albuminuria(P<0.05).Conclusion This study suggests that higher levels of UACR may be associated with an increased risk of osteoporosis in postmenopausal patients with type 2 diabetes.

关 键 词：尿蛋白 肌酐 2型糖尿病 绝经后骨质疏松症 

分 类 号：R587.1[医药卫生—内分泌]