低氧诱导因子1α调控骨代谢和骨微环境血管生成的研究进展  

Research progress of hypoxia-inducible factor 1αin angiogenesis of bone microenvironment

作　　者：张士花 元宇 邹军[1] ZHANG Shihua;YUAN Yu;ZOU Jun(School of Kinesiology, Shanghai University of Sport, Shanghai 200438;School of Physical Education and Sports Science, South China Normal University, Guangzhou 510631,China)

机构地区：[1]上海体育学院运动科学学院,上海200438 [2]华南师范大学体育科学学院,广东广州510631

出　　处：《中国骨质疏松杂志》2020年第8期1201-1206,共6页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金项目(8170223,81572242);中国博士后科学基金项目(2018M640792,2019T120739);上海市人类运动能力开发与保障重点实验室(上海体育学院)项目(11DZ2261100)。

摘　　要：骨微环境血管生成能力的衰退是造成老年性骨质疏松的重要原因之一。老年化导致的骨血管生成能力下降致使骨形成能力减弱,导致骨量流失并诱发骨质疏松。在骨微环境中,骨血管生成能够促进成骨细胞分化,增强骨形成。而成骨细胞则通过分泌VEGF以及FGF2等血管生成因子促进血管内皮细胞的增殖及分化,进而促进骨血管生成。低氧诱导因子1α(HIF-1α)广泛参与骨代谢及血管生成等多个生理过程的调控,且参与骨形成及骨血管生成偶联的调控,在骨血管生成的调控中有着举足轻重的作用。本文主要综述HIF-1α在骨代谢和骨微环境血管生成中的作用机制,为骨血管生成防治骨质疏松的机制研究及骨相关疾病的靶向治疗提供理论基础及研究思路。Decline in angiogenic capacity of the bone microenvironment is one of the important causes of senile osteoporosis.The decreased bone angiogenesis caused by aging leads to weakened bone formation,leading to loss of bone mass and induction of osteoporosis.In the bone microenvironment,the bone angiogenesis promotes osteoblast differentiation and enhances bone formation.Osteoblasts promote the proliferation and differentiation of vascular endothelial cells by secreting angiogenic factors such as VEGF and FGF2,thereby promoting bone angiogenesis.Hypoxia-inducible factor 1α(HIF-1α)is widely involved in the regulation of multiple physiological processes such as bone metabolism and angiogenesis,and is involved in the regulation of bone formation and angiogenesis,and plays a pivotal role in the regulation of bone angiogenesis.This article mainly reviews the mechanism of HIF-1αin bone metabolism and osseointegration of bone microenvironment,and provides theoretical basis and research ideas for the mechanism of osteoporosis prevention and treatment of bone angiogenesis.

关 键 词：低氧诱导因子1Α 骨代谢 血管生成 骨血管 

分 类 号：R681[医药卫生—骨科学]