急性机械性脊髓损伤动物模型研究进展  

Research progress in the establishment of animal models of acute spinal cord injury

作　　者：刘海峰 王斌[1,2] 赵斌 LIU Haifeng;WANG Bin;ZHAO Bin(Department of Orthopaedic,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair,Taiyuan 030001)

机构地区：[1]山西医科大学第二医院骨科,太原030001 [2]骨与软组织损伤修复山西省重点实验室,太原030001

出　　处：《中国实验动物学报》2020年第4期551-556,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(81802204);山西省自然科学基金(201801D22117)。

摘　　要：急性脊髓损伤(acute spinal cord injury,ASCI)是一种致残率高、后果严重的中枢神经系统性损伤,给个人、家庭以及社会带来了沉重的负担。目前仍没有治疗脊髓损伤的有效方法,但包括:干细胞、药物、组织工程的不同治疗手段已经在多种动物模型中进行了应用,并取得一定的效果。动物模型的受伤机制、有效性以及完整性是否可以模拟临床所见,类似的问题依然存在。本文通过阐述几种常见的急性机械性脊髓损伤动物模型的应用及其优缺点,同时也包括常用动物种类和损伤节段的选择,旨在为今后选择更为有效的动物模型提供参考。Acute spinal cord injury is a central nervous system injury with a high disability rate and serious consequences,which brings a heavy burden to individuals,families and society. No effective treatments exist for spinal cord injuries,but different therapies,including stem cells,drugs and tissue engineering have been used in various animal models with some success. Similar questions remain as to whether the mechanism of injury,effectiveness,and integrity of animal models can mimic what is seen clinically. This paper describes the application,advantages,and disadvantages of several common animal models of acute mechanical spinal cord injury,as well as the selection of common animal types and injury segments,to provide references for selecting more effective animal models.

关 键 词：急性脊髓损伤 动物模型 机械性损伤 

分 类 号：Q95-33[生物学—动物学]