轻度胃肠炎伴婴幼儿良性惊厥病原学分析及细胞因子检测的意义  

The significance of etiological analysis and cytokine detection of benign infantile convulsions associated with mild gastroenteritis

作　　者：高鑫 图雅 王育民 杨治理 赵立荣 杨慧敏 梁晓平 张玉玲 李瑞凤 美丽 GAO Xin;TU Ya;WANG Yu-min(Department of Pediatrics,Inner Mongolia Maternal and Child Health Hospital,Hohhot 010020,China)

机构地区：[1]内蒙古自治区妇幼保健院儿内科,010020 [2]内蒙古自治区妇幼保健院检验科,010020

出　　处：《中国实用医药》2020年第24期197-199,共3页China Practical Medicine

基　　金：内蒙古自治区自然科学基金资助(项目编号:2017MS0819)。

摘　　要：目的对轻度胃肠炎伴婴幼儿良性惊厥(BICE)患儿病原学及外周血细胞因子含量进行分析,旨在探讨本区婴幼儿胃肠炎肠道病原的分布情况及可能导致BICE患儿发病的原因,为临床治疗和预防提供有效的实验依据。方法选取80例BICE患儿作为实验组,另选取同期不伴有惊厥发作的80例急性胃肠炎患儿作为对照组。所有BICE患儿入院后均进行病原菌分析,两组患儿均进行外周血炎性因子检查。观察记录BICE患儿病原菌分布情况,比较两组患儿外周血白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。结果80例BICE患儿中45例检出病原菌,阳性率为56.25%(45/80);其中轮状病毒最为常见,检测31例阳性,检测8例诺如病毒阳性、4例柯萨奇病毒阳性、1例EB病毒阳性、1例埃可病毒阳性,未发现细菌感染病例。实验组患儿外周血IL-6(7.19±0.64)pg/ml高于对照组的(5.07±0.71)pg/ml,差异具有统计学意义(P<0.05);实验组患儿外周血TNF-α(1.85±0.31)pg/ml与对照组的(1.77±0.29)pg/ml比较,差异无统计学意义(P>0.05)。结论本区BICE患儿均未出现细菌感染,病毒感染中以轮状病毒和诺如病毒为主;此外,炎性因子IL-6可能与疾病发生发展相关;为疾病治疗和预防提供了有效的细胞学依据。Objective To analyze the etiology and the contents of peripheral blood cytokines in children of benign infantile convulsions associated with mild gastroenteritis(BICE),in order to explore the distribution of intestinal pathogens in infants and young children with gastroenteritis in our region and the possible causes of BICE onset,so as to provide effective experimental basis for clinical treatment and prevention.Methods There were 80 children with BICE as the experimental group,and concurrent 80 acute gastroenteritis children without convulsion as the control group.Etiological analysis was performed in children with BICE after admission,and inflammatory factors tests in the peripheral blood was performed in both groups.The distribution of pathogenic bacteria in BICE children was observed and recorded.The interleukin-6 and tumor necrosis factor-α in the peripheral blood were compared between the two groups.Results In 80 children with BICE,45 cases were positive,the positive rate was 56.25%(45/80);rotavirus was the most common,31 cases were positive,8 cases were norovirus positive,4 cases were Coxsackie virus positive,1 case was EB virus positive,1 case was ecovirus positive,no bacterial infection was found.The level of IL-6 in peripheral blood(7.19±0.64)pg/ml in the experimental group was higher than that of the control group(5.07±0.71)pg/ml,and the difference was statistically significant(P<0.05).The level of TNF-αin peripheral blood(1.85±0.31)pg/ml of the experimental group had no statistically significant difference compared with that of the control group(1.77±0.29)pg/ml(P>0.05).Conclusion None of children with BICE in our district had bacterial infection,and rotavirus and norovirus were the main viral infections.In addition,inflammatory factor IL-6 may be associated with the development of the disease,which provides an effective cytological basis for disease treatment and prevention.

关 键 词：急性胃肠炎 轻度胃肠炎伴良性婴幼儿惊厥 病原菌 免疫失衡 白细胞介素-6 肿瘤坏死因子-α 

分 类 号：R720.597[医药卫生—急诊医学] R725.7[医药卫生—儿科]