地塞米松注射剂联合甲巯咪唑片治疗自身免疫性甲状腺炎患者的临床研究  

Clinical trial of dexamethasone injection combined with methimazole tablets in the treatment of patients with autoimmune thyroiditis

作　　者：叶苗苗[1] 陈娟 张丽敏[1] YE Miao-miao;CHEN Juan;ZHANG Li-min(Department of Endocrinology,Hainan Provincial Cadre Nursing Home,Haikou 571100,Hainan Province,China)

机构地区：[1]海南省干部疗养院内分泌科,海南海口571100

出　　处：《中国临床药理学杂志》2020年第15期2196-2198,共3页The Chinese Journal of Clinical Pharmacology

基　　金：海南省自然科学基金资助项目(20158328)。

摘　　要：目的观察地塞米松注射剂联合甲巯咪唑片治疗自身免疫性甲状腺炎(AIT)患者的临床疗效及安全性。方法将100例AIT患者随机分为对照组和试验组,每组50例。对照组给予甲巯咪唑每次10 mg,tid,口服;试验组在对照组治疗的基础上,给予地塞米松每次5 mg,肌内注射,第1,8,15和22天。2组患者1个疗程均为4周,连续治疗3个疗程。比较2组患者的游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH),以及药物不良反应的发生情况。结果治疗后,试验组和对照组的FT3分别为(2.81±0.94)和(3.52±1.20)pmol·L^-1,FT4分别为(13.17±3.91)和(16.20±4.25)pmol·L^-1,TSH分别为(3.84±1.32)和(4.70±1.53)mU·L^-1,差异均有统计学意义(均P<0.05)。2组患者发生的药物不良反应有头痛头晕、恶心呕吐、激动不安和味觉减退。试验组和对照组的总药物不良反应发生率分别为10.00%和16.00%,差异无统计学意义(P>0.05)。结论地塞米松注射剂联合甲巯咪唑片治疗AIT患者的临床疗效确切,其能有效地改善甲状腺功能,且不增加药物不良反应的发生率。Objective To observe the clinical efficacy and safety of dexamethasone injection combined with methimazole tablets in the treatment of patients with autoimmune thyroiditis(AIT).Methods One hundred patients with AIT were randomly divided into control and treatment groups with 50 cases per group.Control group was given methimazole 10 mg per time,tid,orally.Treatment group was given dexamethasone 5 mg per time,intramuscular injection on days 1,8,15 and 22,on the basis of control group.Two groups were treated for 3 cycles with 4 weeks per cycle.The free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)and adverse drug reactions were compared between two groups.Results After treatment,the main indexes of treatment and control groups:FT3 were(2.81±0.94)and(3.52±1.20)pmol·L^-1,FT4 were(13.17±3.91)and(16.20±4.25)pmol·L^-1,TSH were(3.84±1.32)and(4.70±1.53)mU·L^-1,the differences were statistically significant(all P<0.05).The adverse drug reactions of two groups were headache,dizziness,nausea and vomiting,agitation and loss of taste.The incidences of adverse drug reactions in the treatment and control groups were 10.00% and 16.00% without significant difference(P>0.05).Conclusion Dexamethasone injection combined with methimazole tablets has a definitive clinical efficacy in the treatment of patients with AIT,which can effectively improve the thyroid function,without increasing the incidence of adverse drug reactions.

关 键 词：地塞米松注射剂 甲巯咪唑片 自身免疫性甲状腺炎 甲状腺功能 安全性评价 

分 类 号：R977.14[医药卫生—药品]