伏立康唑致癫■发作及精神障碍一例并文献分析  

Epilepsy seizure and mental disorders caused by voriconazole:one case report and literature analysis

作　　者：刘香芳[1] 蔡婕 滕文兵 倪穗琴[1] LIU Xiangfang;CAI Jie;TENG Wenbing;NI Suiqin(Department of Clinical Pharmacy,Guangzhou First People’s Hospital,Guangzhou 510180,China)

机构地区：[1]广州市第一人民医院临床药学科,广州510180

出　　处：《药学服务与研究》2020年第4期288-290,295,共4页Pharmaceutical Care and Research

基　　金：广东省医学科学技术研究基金(A2019572);广东省医院药学研究基金(2018LR04)。

摘　　要：目的:探讨伏立康唑引起神经系统药品不良反应(ADRs)的特征,为临床合理用药提供参考。方法:对一例伏立康唑引起癫■发作及精神障碍病例的临床表现、高危因素进行分析,并结合相关文献分析其发生机制及防治措施。结果:癫■发作是伏立康唑少见的神经系统ADRs,本例患者伏立康唑血药浓度过高是引发神经系统ADRs的主要原因。结论:临床使用伏立康唑应进行血药浓度监测,实行个体化用药,避免因血药浓度过高引起神经系统ADRs。Objective:To explore the characteristics of voriconazole-induced adverse drug reactions(ADRs)in the nervous system,so as to provide reference for rational drug use clinically.Methods:Clinical manifestations and high risk factors in a case of voriconazole-induced epilepsy seizure and mental disorders were analyzed,and pathogenic mechanism as well as prevention and treatment measures were also analyzed in combination with relevant literature.Results:Epilepsy seizure was rarely seen in neurological ADRs induced by voriconazole.High blood concentration of voriconazole in the patient was the main cause of nervous system ADRs.Conclusion:Blood concentration monitoring of voriconazole was mandatory clinically,and individualized medication should be implemented,so that ADRs in the nervous system could be avoided due to high blood concentration of voriconazole.

关 键 词：伏立康唑 癫■ 精神障碍 药物副反应报告系统 

分 类 号：R994.11[医药卫生—毒理学] R978.5[医药卫生—药学]