四肢恶性骨肿瘤骨切除后大段骨缺损的生物重建  

Biological reconstruction of large bone defects after resection of malignant tumor of extremities

作　　者：贺杰[1] 常祺[1] He Jie;Chang Qi(Hospital of Joint Service Support Force of Chinese PLA,Military Training Medical Research Institute of the Whole Army,Luoyang 471031,Henan Province,China)

机构地区：[1]全军军事训练医学研究所,中国人民解放军联勤保障部队第989医院,河南省洛阳市471031

出　　处：《中国组织工程研究》2021年第3期420-425,共6页Chinese Journal of Tissue Engineering Research

基　　金：2014年度全军后勤科研计划项目(CJN14J005),项目负责人:常祺。

摘　　要：背景:随着医疗技术的发展,恶性骨肿瘤的保肢手术逐步成为主要趋势,因而各种生物重建方法得以在临床中引用。目的:对四肢恶性骨肿瘤骨切除后大段骨缺损的生物重建进行综述。方法:由第一作者应用计算机检索PubMed、Web of science、万方数据库、中国知网中2000至2020年出版的文献,英文检索词为"malignant bone tumor,bone defect,biological reconstruction,limb salvage",中文检索词为"恶性骨肿瘤,保肢方法,生物重建技术"。查阅近年国内外有关肢体恶性骨肿瘤术后大段骨缺损生物重建的文献并进行综述,剔除与研究主题不符的文献,总结各种生物重建手术方式的优缺点。结果与结论:①针对四肢恶性骨肿瘤骨切除后大段骨缺损,瘤段骨原位灭活、关节缺损后生物重建和节段骨切除后生物重建方法各有利弊,对适应证不同的患者应选择不同手术方法;②提示生物重建可为四肢恶性骨肿瘤保肢治疗提供重要方法。BACKGROUND: With the development of medical technology, limb salvage surgery for malignant bone tumors has gradually become the main trend, so various biological reconstruction methods can be cited in the clinic. OBJECTIVE: To review the biological reconstruction of large bone defects after resection of malignant tumor of extremities. METHODS: The literature about the biological reconstruction of large bone defects after resection of malignant tumor of extremities was reviewed in PubMed, Web of Science, Wanfang, and CNKI from 2000 to 2020 by the first author using computer. The English key words were "malignant bone tumor, bone defect, biological reconstruction, limb salvage", and the Chinese key words were "malignant bone tumor, limb salvage, biological reconstruction". The documents that did not match the central words were eliminated, and the advantages and disadvantages of various biological reconstruction surgery methods were summarized. RESULTS AND CONCLUSION:(1) Analyzing the in-situ devitalized tumor-bearing bone, biological reconstruction after resection of juxta-articular osteosarcoma segmental bone tumor, each has its advantages and disadvantages. Surgeons should choose different operation methods based on its different indications.(2) Biological reconstruction provides vital methods for limb salvage of malignant tumor of extremities.

关 键 词：骨 关节 骨肿瘤 恶性 骨缺损 生物重建 保肢 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]