重症MPP患儿D-D、CRP、PAF及血小板参数测定的临床意义  

The clinical significance of D-D,CRP,PAF and platelet parameters in children with severe MPP

作　　者：赵娜[1] 郑华月[1] 乔瑞君[1] ZHAO Na;ZHENG Huayue;QIAO Ruijun(Department of Pediatrics,Second Affiliated Hospital of Nanyang Medical College,Nanyang,Henan,China,473058)

机构地区：[1]南阳医学高等专科学校第一附属医院儿科二病区,河南南阳473058

出　　处：《分子诊断与治疗杂志》2020年第8期1099-1102,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(201706214)。

摘　　要：目的(CRP)、血小板活化因子(PAF)和血小板参数的变化的临床意义。方法选取本院儿科收治的MPP患儿139例,根据病情分为重症组44例、轻症组95例;选择同期健康儿童30例作为对照组,对比各组D-D、CRP、PAF、血小板计数(PLT)、血小板分布宽度(PDW)、平均血小板体积(MPV)、血小板压积(PCT)差异;并对比重症组急性期、恢复期、是否伴有肺实变情况下上述指标的差异。结果重症组、轻症组D-D、CRP、PAF高于对照组(P<0.05),PLT、PCT低于对照组(P<0.05),重症组D-D、CRP、PAF高于轻症组(P<0.05),PLT、PCT低于轻症组(P<0.05),重症组合并肺实变的患儿D-D、CRP、PAF高于未合并肺实变的患儿(P<0.05),PLT、PCT低于未合并肺实变的患儿(P<0.05)。重症组急性期D-D、CRP、PAF高于恢复期(P<0.05);PLT、PCT低于恢复期(P<0.05)。结论MPP患儿处于血液高凝及炎症反应状态,检测D-D、CRP、AFP及血小板参数对病情具有评估价值。Objective To investigate the clinical significance of D-dimer(D-D),C-reactive protein(CRP),platelet activating factor(PAF)and platelet parameters in children with severe Mycoplasma pneumoniae pneumonia(MPP).Method 139 children with MPP in our hospital were divided into the severe group(44 cases)and the mild group(95 cases),30 healthy children in the same period were selected as the control group,and the differences of D-D,CRP,PAF,PLT,PDW,MPV and PCT were compared in each group.The levels of D-D,CRP,PAF,PLT,PDW,MPV and PCT were compared between acute stage and recovery stage,and whether or not with pulmonary consolidation.Results The levels of D-D,CRP and PAF were higher in the severe group and light group than those in the control group(P<0.05),PLT and PCT were lower in the severe group and light group than those in the control group(P<0.05),D-D,CRP and PAF were higher in the severe group than those in the mild group(P<0.05),PLT and PCT were lower in the severe group than those in the mild group(P<0.05),D-D,CRP and PAF in the severe group were higher with pulmonary consolidation than thosewith no pulmonary consolidation(P<0.05),PLT and PCT were lower with pulmonary consolidation than those with no pulmonary consolidation(P<0.05).D-D,CRP and PAF in the severe group were higher in acute stage than those in recovery stage(P<0.05),while PLT and PCT were lower in acute stage than those in recovery stage(P<0.05).Conclusions Children with MPP are in a state of hypercoagulability and inflammatory reaction.The detection of D-D,CRP,AFP and platelet parameters has an evaluation value for the disease.

关 键 词：重症肺炎 支原体 清D-二聚体 C反应蛋白 血小板活化因子 血小板参数 

分 类 号：R725.6[医药卫生—儿科]