不同妊娠时期妊娠期糖尿病患者糖脂代谢状况及妊娠结局分析  

Glucolipid metabolism status and pregnancy outcome in patients with gestational diabetes at different gestational periods

作　　者：史俊霞 尹盼月 SHI Jun-xia;YIN Pan-yue(Department of Obstetrics and Gynecology,the Affiliated Hanjiang Hospital of Xi’an Medical University,Hanzhong 723003,Shaanxi,CHINA;Department of Gynecology,the People's Hospital of Baoji City,Baoji 721000,Shaanxi,CHINA)

机构地区：[1]西安医学院附属汉江医院妇产科,陕西汉中723003 [2]宝鸡市人民医院妇科,陕西宝鸡721000

出　　处：《海南医学》2020年第16期2082-2085,共4页Hainan Medical Journal

摘　　要：目的探讨不同妊娠时期妊娠期糖尿病患者糖脂代谢状况及妊娠结局,为患者的临床诊疗提供指导。方法选取2017年1月至2019年6月于西安医学院附属汉江医院产检并分娩的126例妊娠期糖尿病患者为研究组。根据产检的不同妊娠时期,将其分为妊娠早期组(46例)、妊娠中期组(42例)和妊娠晚期组(38例),并选取同期70例正常妊娠孕妇为对照组。检测并比较四组孕妇的空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,并分析其妊娠结局。结果妊娠早期组、妊娠中期组和妊娠晚期组患者的FPG、TC、TG、LDL-C水平分别为(4.54±0.81)mmol/L、(5.33±0.88)mmol/L、(2.02±0.59)mmol/L、(2.83±0.65)mmol/L;(5.37±0.87)mmol/L、(6.02±1.14)mmol/L、(3.08±0.66)mmol/L、(3.47±0.71)mmol/L;(6.02±0.94)mmol/L、(6.64±1.16)mmol/L、(4.12±0.80)mmol/L、(3.94±0.73)mmol/L,均明显高于对照组的(4.06±0.74)mmol/L、(4.05±0.74)mmol/L、(1.28±0.47)mmol/L、(2.30±0.62)mmol/L,且妊娠晚期组患者的FPG、TC、TG、LDL-C水平均明显高于妊娠早期组、妊娠中期组,妊娠中期组患者的FPG、TC、TG、LDL-C水平均明显高于妊娠早期组,差异均有统计学意义(P<0.05);妊娠早期组、妊娠中期组和妊娠晚期组患者的不良妊娠结局发生率分别为17.39%、35.71%、57.89%,均明显高于对照组的5.71%,且妊娠晚期组患者的不良妊娠结局发生率明显高于妊娠早期组、妊娠中期组,妊娠中期组患者的不良妊娠结局发生率明显高于妊娠早期组,差异均有统计学意义(P<0.05)。结论妊娠期糖尿病患者的糖脂代谢异常状况随其妊娠的发展而加重,且糖脂代谢异常状况越严重,其不良妊娠结局发生率越高,孕妇妊娠早期检测糖脂代谢状况对诊断妊娠期糖尿病、预测妊娠结局具有重要意义。Objective To investigate the glucolipid metabolism status and pregnancy outcomes in patients with gestational diabetes at different gestational stages,and to provide guidance for clinical diagnosis and treatment.Methods A total of 126 gestational diabetes patients who examined and delivered in the Affiliated Hanjiang Hospital of Xi'an Medical University from January 2017 to June 2019 were selected as the study group.According to the different gestational periods during pregnancy,they were divided into early pregnancy group(46 cases),middle pregnancy group(42 cases)and late pregnancy group(38 cases),and 70 normal pregnant women during the same period were selected as the control group.The levels of fasting blood glucose(FPG),total cholesterol(TC),triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)in the four groups of pregnant women were detected and compared,and the pregnancy outcome were analyzed.Results The levels of FPG,TC,TG,and LDL-C of patients in the early pregnancy group,the middle pregnancy group,and the late pregnancy group were(4.54±0.81)mmol/L,(5.33±0.88)mmol/L,(2.02±0.59)mmol/L,(2.83±0.65)mmol/L;(5.37±0.87)mmol/L,(6.02±1.14)mmol/L,(3.08±0.66)mmol/L,(3.47±0.71)mmol/L;(6.02±0.94)mmol/L,(6.64±1.16)mmol/L,(4.12±0.80)mmol/L,(3.94±0.73)mmol/L,respectively,which were significantly higher than(4.06±0.74)mmol/L,(4.05±0.74)mmol/L,(1.28±0.47)mmol/L,(2.30±0.62)mmol/L in control group,and the levels of FPG,TC,TG,LDL-C levels in the late pregnancy group were significantly higher than those of the early pregnancy group and the middle pregnancy group,and also in the middle pregnancy group than the early pregnancy group(P<0.05).The incidence of adverse pregnancy outcomes in the early pregnancy group,middle pregnancy group,and late pregnancy group were 17.39%,35.71%,57.89%,respectively,which were significantly higher than 5.71%in the control group,and the incidence of adverse pregnancy outcomes in the late pregnancy group was significantly higher t

关 键 词：妊娠期糖尿病 妊娠时期 糖脂代谢 空腹血糖 血脂 妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]