干细胞来源外泌体在创伤性脑损伤修复中的作用与热点  

Role and hotspots of stem cell-derived exosome in the repair of traumatic brain injury

作　　者：孙田静 刘思佳 谢方可 黄晓飞 张吉 姜栩恒 冯华 喻安永 Sun Tianjing;Liu Sijia;Xie Fangke;Huang Xiaofei;Zhang Ji;Jiang Xuheng;Feng Hua;Yu Anyong(Department of Emergency,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China;Department of Neurosurgery,Southwest Hospital,Army Medical University,Chongqing 400038,China)

机构地区：[1]遵义医科大学附属医院急诊科,贵州省遵义市563000 [2]陆军军医大学西南医院神经外科,重庆市400038

出　　处：《中国组织工程研究》2021年第1期123-127,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81560217),项目负责人:喻安永;贵州省科技计划项目([2019]5661),项目负责人:喻安永。

摘　　要：背景:创伤性脑损伤的治疗与预后是目前临床工作中的难点。越来越多的研究表明干细胞来源外泌体在创伤性脑损伤中表现出独特的优势,具有更大的神经治疗潜力,或许能从本质上恢复神经血管的功能及促进神经元的再生,为创伤性脑损伤的治疗提供新的思路。目的:综述干细胞来源外泌体在创伤性脑损伤中的应用及优势。方法:第一作者应用计算机检索PubMed和中国知网数据库中关于外泌体的文献,以"创伤性脑损伤,外泌体,干细胞"为中文检索词,以"traumatic brain injury,exosomes,stem cells"为英文检索词进行检索,选择53篇文献进行综述。结果与结论:①经过大量的创伤性脑损伤动物实验,证明神经细胞及干细胞可分泌外泌体;②神经细胞及干细胞来源外泌体都对创伤性脑损伤的治疗有积极的作用,但干细胞来源外泌体对神经、血管再生及神经功能恢复效果更佳;③干细胞来源外泌体可能会开启创伤性脑损伤治疗的全新途径。BACKGROUND:The treatment and prognosis of traumatic brain injury are difficult points in clinical work at present.More and more studies have shown that exosomes derived from stem cells show unique advantages in traumatic brain injury,which may have greater neurotherapeutic potential in the treatment of traumatic brain injury,and may essentially restore neurovascular function and promote neuronal regeneration,thereby providing new ideas for the treatment of traumatic brain injury.OBJECTIVE:To review the application and advantages of exosomes derived from stem cells in traumatic brain injury.METHODS:A computer-based search was performed in the PubMed and CNKI databases for articles addressing exosomes.The keywords were“Traumatic brain injury, Exosomes, Stem cells” in English and Chinese, respectively. Finally, 53 articles were included for review.RESULTS AND CONCLUSION: (1) A large number of traumatic brain injury animal experiments proved that nerve cells and stem cells can secrete exosomes.(2) Exosomes derived from nerve cells and stem cells play a positive role in the treatment of traumatic brain injury, but the exosomes derived from stem cellsare more effective in nerve, vascular regeneration and neurofunctional recovery. (3) The exosomes derived from stem cells may open up a new approach totraumatic brain injury.

关 键 词：干细胞 外泌体 骨髓间充质干细胞 脑损伤 实验 再生 综述 

分 类 号：R459.9[医药卫生—治疗学] R394.2[医药卫生—临床医学]