高血脂病人载脂蛋白E基因多态性与心肌梗死相关性  

ApoE gene polymorphism in hyperlipidemia patients and its correlation with myocardial infarction

作　　者：胡耀[1] 谭昀 桂绍涛 王洪[1] 杨柳[1] HU Yao;TAN Yun;GUI Shaotao;WANG Hong;YANG Liu(Department of Cardiovascular Medicine,Jiangxi Provincial People’s Hospital Affiliated to Nanchang University,Nanchang,Jiangxi 330000,China;People’s Hospital of Jinxian County,Nanchang City,Nanchang,Jiangxi 330000,China)

机构地区：[1]江西省人民医院、南昌大学附属人民医院心血管内科,江西南昌330000 [2]南昌市进贤县人民医院心血管内科,江西南昌330000

出　　处：《安徽医药》2020年第9期1753-1756,共4页Anhui Medical and Pharmaceutical Journal

基　　金：江西省健康委员会项目(20195014)。

摘　　要：目的探寻载脂蛋白E(ApoE)基因多态性与心肌梗死之间的相关性。方法选取2017年1—6月江西省人民医院685例高脂血症病人进行ApoE基因型检测(其中心肌梗死病人53例,非心肌梗死病人632例)。随后进行统计学分析。结果检测出三组ApoE型:E2表型组(E2/E2,E2/E3)、E3表型组(E3/E3,E3/E4)、E4表型组(E2/E4,E4/E4)。其中,E3表型组占大多数(440例)。同时,心肌梗死组E2表型组、E3表型组与非心肌梗死组对比,差异无统计学意义(P>0.05);而ApoE E4组等位基因(171人)与心肌梗死密切相关联(E2/E4:13.5%比4.33%,E4/E4:11.23%比2.18%,均P<0.05)。结论ApoE E3基因型占大多数,ApoE E4等位基因与心肌梗死密切相关。Objective To observe the correlation between apolipoprotein E(ApoE)gene polymorphism and myocardial infarction(AMI).Methods A total of 685 patients with hyperlipidemia(53 patients were MI and 632 patients were non⁃MI)in Jiangxi Pro⁃vincial People’s Hospital Affiliated to Nanchang University from January to June 2017 were selected for ApoE genotyping.Statisti⁃cal analysis was then performed.Results Three genotypes of ApoE were detected,namely E2 genotype(E2/E2,E2/E3),E3 geno⁃type(E3/E3,E3/E4)and E4 genotype(E2/E4,E4/E4),of which E3/E3 genotype accounted for the majority(440 persons).In the meantime,there was no significant difference between E2 genotype and E3 genotype in myocardial infarction group and non⁃myocar⁃dial infarction group.ApoE E4 allele(171 persons)(E2/E4:13.5%vs.4.33%,E4/E4:11.23%vs.2.18%,both P<0.05)was close⁃ly related to myocardial infarction.Conclusion ApoE E3 genotype accounts for the majority among 685 patients.ApoE E4 allele is closely related to myocardial infarction.

关 键 词：高脂血症 载脂蛋白E类 多态现象 遗传 心肌梗死 

分 类 号：R589.2[医药卫生—内分泌] R542.22[医药卫生—内科学]