绍兴地区女性高危型人乳头状瘤病毒感染的流行病学调查  

Epidemiological investigation of female high risk human papillomavirus infection in Shaoxing area

作　　者：郑嘉来 叶春艳[1] 沈芳[1] 屠湧涛 童海江[1] ZHENG Jia-lai;YE Chun-yan;SHEN Fang;TU Yong-tao;TONG Hai-jiang(Laboratory Department,the Second Hospital of Shaoxing,Shaoxing,Zhejiang 312000,China)

机构地区：[1]绍兴第二医院检验科,浙江绍兴312000

出　　处：《中国卫生检验杂志》2020年第14期1785-1788,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的了解绍兴地区女性高危型人乳头状瘤病毒(HR-HPV)感染的最新流行趋势和亚型分布情况,为宫颈癌的防治提供数据支持。方法收集2016年1月-2018年12月来本院检查或就诊的门诊、住院和体检女性标本9 174例,按年龄分为青年组(≤35岁) 2 764例、中年组(36岁~59岁) 5 855例、老年组(≥60岁) 555例3组。采用荧光定量PCR法检测HPV 15种高危型,用SPSS 25.0软件分析结果。结果共收集标本9 174例,HPV阳性标本1 390例,阳性率为15.15%;3年间HPV阳性率呈上升趋势,分别为9.37%(208/2 220)、15.08%(493/3 270)、18.70%(689/3 684)(χ趋势^2=92.140,P <0.01)。年龄分布以中年为主(占59.50%),感染亚型分布以单一感染为主(占79.14%),高危亚型以HPV52(占28.71%)、HPV16(占18.20%)、HPV58(占17.77%)为主。结论绍兴地区HPV52阳性率最高与本地区早期调查以及其他地区的研究结果不同。另外,HPV阳性率在2016年-2018年呈递增的趋势,应加强预防治疗措施。Objective To understand the latest epidemiological trend and the genotypes of high-risk human papilloma virus( HR-HPV) among women in Shaoxing,and to provide data support for the prevention and treatment of cervical cancer.Methods A total of 9 174 female specimens of outpatient,inpatient and health examination in our hospital from January 2016 to December 2018 were collected. They were divided into three groups according to age: 2 764 cases in young group( ≤ 35 years old),5 855 cases in middle-aged group( 36-59 years old) and 555 cases in old group( ≥ 60 years old). Fifteen types of HR-HPV were detected by fluorescence quantitative PCR,and the results were analyzed by SPSS 25. 0. Results A total of 9 174 specimens were collected,and 1 390 specimens were HPV infection. The positive rate was 15. 15%. The infection rate of HPV showed an upward trend in three years,which was 9. 37%( 208/2220),15. 08%( 493/3270) and 18. 70%( 689/3 684)( χtrend^2= 92. 140,P < 0. 01). The age distribution was mainly middle-aged( 59. 50%). The distribution of infection subtypes was mainly single infection,accounting for 79. 14%. High-risk subtypes were HPV52( 28. 71%),HPV16( 18. 20%) and HPV58( 17. 77%). Conclusion The highest positive rate of HPV52 in Shaoxing is different from the results of early investigation and other areas. In addition,the positive rate of HPV increased from 2016 to 2018,and preventive and therapeutic measures should be strengthened.

关 键 词：高危型人乳头状瘤病毒 流行病学 宫颈癌 荧光定量PCR 

分 类 号：R446.5[医药卫生—诊断学]