骨形态发生蛋白在关节软骨再生过程中的作用与应用  

Role and application of bone morphogenetic proteins in articular cartilage regeneration

作　　者：邓桢翰 黄勇 肖璐璐 陈昱霖 朱伟民[1] 陆伟[1] 王大平[1] Deng Zhenhan;Huang Yong;Xiao Lulu;Chen Yulin;Zhu Weimin;Lu Wei;Wang Daping(Department of Sports Medicine,the First Affiliated Hospital of Shenzhen University,Shenzhen Second People’s Hospital,Shenzhen 518035,Guangdong Province,China;Department of Clinical Medicine,Shenzhen University,Shenzhen 518000,Guangdong Province,China;Baishilong Community Health Service Center,Shenzhen Longhua People’s Hospital,Shenzhen 518000,Guangdong Province,China)

机构地区：[1]深圳大学第一附属医院,深圳市第二人民医院运动医学科,广东省深圳市518035 [2]深圳大学医学部临床医学系,广东省深圳市518000 [3]深圳市龙华区人民医院白石龙社区健康服务中心,广东省深圳市518000

出　　处：《中国组织工程研究》2021年第5期798-806,共9页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81902303),项目负责人:邓桢翰;广东省基础与应用基础研究基金项目(2020A1515011046),项目负责人:邓桢翰。

摘　　要：背景:关节软骨退变是导致骨关节炎最主要的原因。骨形态发生蛋白在软骨再生和修复中起着重要作用。目的:综述骨形态发生蛋白在关节软骨再生过程中的作用和应用研究进展。方法:应用计算机检索PubMed数据库及Elsevier数据库,检索词为“bone morphogenetic proteins,BMPs,arthritis,osteoarthritis,OA,cartilage,chondrocyte”,共检索到相关文献272篇,最终选取符合标准的文献96篇,对其进行分析、归纳和总结,还有27篇文献为概念类相关文献,最终纳入文献123篇。结果与结论:骨形态发生蛋白参与了包含细胞增殖、分化、迁移、凋亡等诸多生物学过程,在骨和软骨形成过程中发挥了重要作用。骨形态发生蛋白通过与不同的受体结合,参与了多种信号通路级联反应,保护关节软骨免受炎症、创伤等导致的软骨破坏。骨形态发生蛋白单独或与其他细胞因子联合使用能够修复软骨缺损和改善退行性病变,促进关节软骨细胞的分化和再生。但是目前将骨形态发生蛋白广泛应用于软骨再生还有一些实际问题亟待解决,例如缺乏有效的生物支架材料,使用生物制剂的最优剂量和作用时间点及其毒副作用等。今后的研究将围绕如何解决以上问题开展,骨形态发生蛋白的广泛应用将为软骨损伤和以骨关节炎为代表的软骨退行性病变的靶向治疗开启新的纪元。BACKGROUND:Articular cartilage degeneration is the main cause of osteoarthritis.Bone morphogenetic proteins play an important role in cartilage regeneration and repair.OBJECTIVE:To review the research progress of bone morphogenetic protein in the process of articular cartilage regeneration.METHODS:A computer-based online search of PubMed and Elsevier databases was performed using the keywords“bone morphogenetic proteins,BMPs,arthritis,osteoarthritis,OA,cartilage,chondrocyte”in English.A total of 272 papers were retrieved,96 of which were included in final analysis.Another 27 papers related to concepts were also included.Therefore,123 papers are finally included.RESULTS AND CONCLUSION:Bone morphogenetic proteins participate in many biological processes including cell proliferation,differentiation,migration,and apoptosis,and play an important role in the formation of bone and cartilage.Bone morphogenetic proteins participate in a variety of signaling pathway cascades by binding to different receptors,which can protect articular cartilage from cartilage destruction caused by inflammation and trauma.Bone morphogenetic proteins alone or in combination with other cytokines can repair cartilage defects improve degenerative lesions,and promote the differentiation and regeneration of articular chondrocytes.However,there are still some practical problems that need to be solved for the widespread use of bone morphogenetic proteins in cartilage regeneration,such as the safety of drug transporters,the lack of effective biological scaffold materials,the optimal dosage and time point of use of biological agents,and their toxic and side effects.Future research will focus on how to solve the above problems.The widespread application of bone morphogenetic proteins will open a new era for targeted treatment of cartilage damage and cartilage degenerative diseases represented by osteoarthritis.

关 键 词：骨 骨形态发生蛋白 关节软骨 软骨细胞 骨关节炎 软骨再生 软骨损伤 生物制剂 成软骨分化 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]