丙戊酸钠联合拉莫三嗪片对脑卒中后癫痫患者认知功能、GFAP、NMDAR1、Bcl-2及Bax表达的影响分析  

Effect of Sodium Valproate Combined with Lamotrigine Tablets on Cognitive Function,GFAP,NMDAR1,Bcl-2 and Bax Expression in Patients with Epilepsy after Stroke

作　　者：王晶 WANG Jing(No.1 Ward of Neurology Department,First People's Hospital of Lingbao City,Sanmenxia Henan 4752500,China)

机构地区：[1]河南省三门峡灵宝市第一人民医院神经内科一病区,河南三门峡4752500

出　　处：《药品评价》2020年第9期35-37,共3页Drug Evaluation

基　　金：河南省卫生科技创新型人才工程(编号201003040)。

摘　　要：目的:分析丙戊酸钠联合拉莫三嗪片对脑卒中后癫痫患者认知功能、胶质纤维酸性蛋白(GFAP)、N-甲基-D-天门冬氨酸受体1(NMDAR1)、抑制神经元凋亡因子(Bcl-2)及神经元凋亡因子(Bax)表达的影响。方法:以86例于2017年1月—2019年1月入院治疗的脑卒中后癫痫患者作对象,随机分作2组,各43例,对照组用药丙戊酸钠治疗,实验组在此基础上联合用药拉莫三嗪片,对比两组认知功能、GFAP、NMDAR1、Bcl-2及Bax表达。结果:治疗后,实验组总智商、语言智商以及操作智商评分均比对照组高(P<0.05);实验组GFAP(22.88±3.90)n g/m L,NMDAR1(2.55±1.47)ng/L,分别比对照组(30.00±3.95)ng/mL及(4.47±1.23)ng/L低(P<0.05);实验组Bcl-2(36.06±3.70)pg/mL,比对照组(30.02±3.20)pg/mL高,而实验组Bax(20.29±1.31)pg/mL,比对照组(27.11±1.52)pg/mL低(P<0.05)。结论:丙戊酸钠联合拉莫三嗪片治疗脑卒中后癫痫有助于改善患者认知功能、GFAP、NMDAR1、Bcl-2及Bax表达,值得推广。Objective:To analyze the cognitive function,glial fibrillary acidic protein(GFAP)and N-methyl-D-aspartic acid of sodium valproate combined with lamotrigine tablets in patients with epilepsy after stroke N-methyl-D-aspartate receptor 1,NMDAR1,neuronal apoptosis factor(B-cell lymphoma 2,Bcl-2)and neuronal apoptosis factor(B-cell lymphoma-2 associated X protein,Bax).Methods:86 patients with post-stroke epilepsy admitted to hospital from January 2017 to January 2019 were randomly divided into 2 groups,each with 43 cases.The control group was treated with sodium valproate,and the experimental group was based on the combination of lamotrigine tablets compared the cognitive function,GFAP,NMDAR1,Bcl-2 and Bax expressions of the two groups.Results:After treatment,the total IQ,language IQ and operation IQ scores of the experimental group were higher than the control group(P<0.05);GFAP(22.88±3.90)ng/mL and NMDAR1(2.55±1.47)ng/mL of the experimental group,respectively Compared with the control group(30.00±3.95)ng/mL and(4.47±1.23)ng/mL(P<0.05);the experimental group Bcl-2(36.06±3.70)pg/mL,compared with the control group(30.02±3.20)pg/mL is higher,while the experimental group Bax(20.29±1.31)pg/mL is lower than the control group(27.11±1.52)pg/mL(P<0.05).Conclusion:Sodium valproate combined with lamotrigine tablets in the treatment of post-stroke epilepsy is helpful to improve patients'cognitive function,GFAP,NMDAR1,Bcl-2 and Bax expression,which is worthy of promotion.

关 键 词：丙戊酸钠 拉莫三嗪片 脑卒中 癫痫 认知功能 

分 类 号：R971[医药卫生—药品]