调环酸钙的合成工艺研究  

Synthesis of prohexadione calcium

作　　者：彭浩源 陈宁萱 田昊 李正阳 夏强强 张俨娜 徐浩[1] PENG Haoyuan;CHEN Ningxuan;TIAN Hao;LI Zhengyang;XIA Qiangqiang;ZHANG Yanna;XU Hao(College of Chemistry and Chemical Engineering,Henan Uniersity,Kaifeng 475004,Henan,China;School of Civil Engineering and Architecture,Henan University,Kaifeng 475004,Henan,China;Department of Laboratory and Equipment Management,Henan University,Kaifeng 475004,Henan,China)

机构地区：[1]河南大学化学化工学院,河南开封475004 [2]河南大学土木建筑学院,河南开封475004 [3]河南大学实验室与设备管理处,河南开封475004

出　　处：《化学研究》2020年第3期229-232,共4页Chemical Research

基　　金：河南大学2018年大学生创新创业项目(201815007).

摘　　要：以3,5⁃二羟基苯甲酸为原料,经过酯化、加氢、酰化、重排、水解等过程得到目标产物,对反应过程中压强、溶剂等条件进行了优化.中间产物和产品的结构均经^1 H NMR和^13 C NMR进行了表征.该合成路线中所用的溶剂大多可以回收套用,中间产物不需要分离,污染小,成本低,适合工业化生产.Prohexadione calcium was prepared using 3,5⁃dihydroxybenzoic acid as raw material,through the processes of esterification,hydrogenation,acylation,rearrangement and hydrolysis.The effects of pressure and solvent were studied.The intermediate and final products were characterized by ^1H NMR and ^13C NMR.Most of the solvents can be recovered and reused,and the intermediate products do not need to be separated.The process has the advantage of low⁃cost and less⁃pollution,which is suitable for industrial production.

关 键 词：调环酸钙 酰化反应 重排反应 3 5⁃二羟基苯甲酸 

分 类 号：O26[理学—数学]