软坚散结法治疗甲状腺结节有效性和安全性Meta分析  

Meta-analysis of the Effectiveness and Safety of Soften Hardness and Dissipate Masses Method in the Treatment of Thyroid Nodules

作　　者：刘彩凤 赵汉青 李思婷 雷新霞 王志国[1] LIU Caifeng;ZHAO Hanqing;LI Siting;LEI Xinxia;WANG Zhiguo(Institute of Clinical Basic Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;He Bei University,Baoding 071002,China;Kaifeng Traditional Chinese Medicine Hospital,Kaifeng 475000,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]河北大学,保定071002 [3]河南省开封市中医院,开封475000

出　　处：《世界中医药》2020年第16期2397-2403,共7页World Chinese Medicine

基　　金：国家科技部基础性工作专项资助项目(2008FY230500)。

摘　　要：目的:系统评价具有软坚散结功效的中药复方治疗甲状腺结节的疗效和安全性。方法:检索具有软坚散结功效的中药复方治疗甲状腺结节的RCTs,进行方法学质量评价并提取数据,用Revman5.3软件进行Meta分析。结果:纳入34篇临床随机对照试验。分析结果显示中药+西药组vs西药组、中药组vs西药组,在总有效率、甲状腺结节直径缩小方面差异有统计学意义。结论:中药治疗甲状腺结节疗效优于西药治疗,且不良反应少,相对安全。Objective:To systematically evaluate the efficacy and safety of Chinese herbal Compound Formula with soften hardness and dissipate masses efficacy in the treatment of thyroid nodules.Methods:RCTs of Chinese herbal compound formula with soften hardness and dissipate masses efficacy in the treatment of thyroid nodules were retrieved,methodological quality were evaluated and data was extracted,Revman5.3 software was used for Meta analysis.Results:A total of 34 clinical randomized controlled trials were included.The analysis results showed that there were statistically significant differences in the total effective rate and the reduction of the diameter of thyroid nodules between the Chinese medicine+western medicine group vs western medicine group,and between the Chinese medicine group vs western medicine group.Conclusion:Traditional Chinese medicine is more effective than western medicine in the treatment of thyroid nodules,with fewer adverse reactions and relatively safe.

关 键 词：中医药 META分析 甲状腺结节 结节性甲状腺肿 软坚散结法 

分 类 号：R259[医药卫生—中西医结合]