中药口服对经内镜摘除后大肠腺瘤防治作用的Meta分析  

Meta analysis of the Prevention and Treatment of Colorectal Adenoma by Oral Administration of Traditional Chinese Medicine after Endoscopic Removal

作　　者：林燕端 邓晓敏 傅诗书 LIN Yanduan;DENG Xiaomin;FU Shishu(Bao′an District Hospital of Traditional Chinses Medicine Affiliated to Guangzhou University of Chinese Medicine,Shenzhen 518000,China)

机构地区：[1]广州中医药大学附属宝安中医院,深圳518000

出　　处：《世界中医药》2020年第16期2408-2413,共6页World Chinese Medicine

基　　金：2018年广东省中医药局科研项目(20182029)。

摘　　要：目的:评价中药口服对经内镜摘除后大肠腺瘤的防治作用。方法:搜索Pubmed、Embase、Web of science、CBM、万方数据库、中国知网、维普数据库、Cochrane Library中关于中医药防治大肠腺瘤息肉术后的临床随机对照实验的文献。对纳入文献进行筛选、提取,评估,运用Review Manager 5.3软件进行Meta分析。结果:共纳入13篇文献,1103例患者,以临床有效率为观察指标的有5篇,异质性检验Chi2=0.67、df=4(P=0.96)、I^2=0%,使用固定效应模型统计OR=3.56,95%CI:[2.03,6.23],Z=4.45(P<0.00001),观察组优于对照组,2组临床疗效差异有统计学意义。以半年复发率为观察指标的有10篇,异质性检验Chi2=9.26、df=9(P=0.41)、I^2=3%,使用固定效应模型合并统计量OR=3.29,95%CI:[2.30,4.69],Z=6.54(P<0.00001),观察组复发率低于对照组,差异有统计学意义;以1年复发率为观察指标的有7篇,异质性检验Chi2=6.01、df=6(P=0.42)、I^2=3%,使用固定效应模型合并统计量OR=4.21,95%CI:[2.88,6.16],Z=7.41(P<0.00001),观察组复发率低于对照组,差异有统计学意义。结论:中药口服对降低内镜下切除大肠腺瘤复发率有效,同时改善术后腹痛腹泻症状,以参苓白术散加减为代表的健脾方药具有良好的临床疗效。Objective:To evaluate oral administration of traditional Chinese medicine on colorectal glands after endoscopic removal.Methods:Related databases at home and abroad was searched.The included literature was screened,extracted and evaluated.Review Manager 5.3 software was used for META analysis.Results:A total of 13 papers were including 1103 patients,5 of which used clinically efficacy as observation indicators,heterogeneity test Chi2=0.67,df=4(P=0.96),I^2=0%.Fixed effect model statistics was used OR=3.56,95%CI:[2.03,6.23],Z=4.45(P<0.00001),the observation group was superior to the control group,and the clinical efficacy difference between the 2 groups was statistically significant.There were 10 observation indicators with a half-year recurrence rate,heterogeneity test Chi2=9.26,df=9(P=0.41),I^2=3%.A fixed effect model combined statistics was used OR=3.29,95%CI:[2.30,4.69],Z=6.54(P<0.00001),the recurrence rate of the observation group was lower than that of the control group,the difference was statistically significant;there were 7 observation indicators based on the 1-year relapse rate,heterogeneity test Chi2=6.01 df=6(P=0.42),I^2=3%.Fixed effect model combined statistics was used OR=4.21,95%CI:[2.88,6.16],Z=7.41(P<0.00001),the recurrence rate of the observation group was lower than that of the control group,the difference is statistically significant.Conclusion:Oral Chinese medicine is effective in reducing the recurrence rate of colorectal adenoma under endoscopic resection,and at the same time improving the symptoms of abdominal pain and diarrhea after surgery.The prescription medicine of invigorating spleen represented by Shenling Baizhu Powder has good clinical effects.

关 键 词：中药 参苓白术散 健脾 大肠腺瘤 防治 经内经切除 复发率 临床疗效 Meta分析。 

分 类 号：R289.4[医药卫生—方剂学]