紫杉醇对卵巢癌、乳腺癌、宫颈癌的抗癌功效及生物分子机制研究进展  

The Effects and Molecular Mechanisms of Paclitaxel in Prevention and Treatment of Cancers

作　　者：冯巧惠 李琼 贺延苓 蔡昌兰 FENG Qiao hui;LI Qiong;HE Yan-ling;CAI Chang-lan(The Sixth Medical Center of PLA General Hospital,Beijing 100048,China)

机构地区：[1]中国人民解放军总医院第六医学中心,北京100048

出　　处：《药物生物技术》2020年第3期278-280,共3页Pharmaceutical Biotechnology

基　　金：海军总医院护理创新培育基金资助项目(HLCX-2016-09)。

摘　　要：紫杉醇是一种二萜类生物碱,主要从红豆杉中提取获得,属于天然抗癌药物。因其具有显著的抗癌功效,在药品和食品等行业应用广泛。文章主要就紫杉醇及其新型制剂对卵巢癌、乳腺癌和宫颈癌的治疗效果及其分子机制研究进展进行综述,以期为紫杉醇及其制剂在抗癌方面深入研究提供理论基础和临床依据。Paclitaxel was a diterpenoid alkaloid,derived from the pacific yew berry,which raises attentions due to exhibiting antineoplastic effects against various types of cancers.Because of its remarkable anticancer effects,it is widely used in medicine,food and other industries.Thetherapeutic effect of paclitaxel and its new preparations on ovarian cancer,breast cancer andcervical cancer and its molecular mechanisms were summerized,in order to provide theoretical basis and clinical basis for the further study of paclitaxel and its novel preparations in anticancer.

关 键 词：紫杉醇 紫杉醇新型制剂 卵巢癌 乳腺癌 宫颈癌 分子机制 

分 类 号：R282.71[医药卫生—中药学]