One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles  

作　　者：Mingyue Cui Christian Wiraja Lim Wei Qi Sharon Chew Wan Ting Deblin Jana Mengjia Zheng Xiao Hu Chenjie Xu 

机构地区：[1]Nanyang Environment&Water Research Institute,Interdisciplinary Graduate Programme,Nanyang Technological University,Singapore,637141,Singapore [2]School of Chemical and Biomedical Engineering,Nanyang Technological University,Singapore,637457,Singapore [3]School of Materials Science and Engineering,Nanyang Technological University,Singapore,639798,Singapore [4]Division of Chemistry and Biological Chemistry,School of Physical and Mathematical Sciences,Nanyang Technological University,Singapore,637371,Singapore [5]National Dental Centre of Singapore,5 Second Hospital Ave,Singapore,168938,Singapore [6]Department of Biomedical Engineering,City University of Hong Kong,83 Tat Chee Avenue,Kowloon,Hong Kong,China

出　　处：《Nano Research》2020年第6期1592-1596,共5页纳米研究（英文版）

基　　金：This work was supported by Singapore MOE Academic Research Fund(AcRF)Tier 1 grant(RG49/18);Additive Manufacturing for Biological Materials(AMBM)program from Singapore A*STAR Science and Engineering Research Council(A18A8b0059).

摘　　要：Silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility,controllable morphology and so on.They can be used both as the drug carrier and imaging vehicle.Here,an aminated ultra-small silica nanoparticle based system is developed with various functionalities.Multiple molecules including fluorophore,folic acid,and antibody are coupled to this system to achieve specific applications such as bacterial/cell labelling and recognition.

关 键 词：silica nanoparticles one-step synthesis surface modification bacterial&cell labelling 

分 类 号：TB383[一般工业技术—材料科学与工程]