白芍总苷治疗老年中重度斑块状银屑病的临床观察  

Efficacy and safety of total glucosides of paeony in the treatment of moderate to severe plaque psoriasis in the elderly

作　　者：常红阳 王超美[2] 邓秀娥[1] 汪舰笛 董玉兰[2] 张兆翠[1] 吴先伟[1] Chang Hong-yang;Wang Chao-mei;Deng Xiu-e;Wang Jian-di;Dong Yu-lan;Zhang Zhao-cui;Wu Xian-wei(Department of Dermatology,Gansu Provincial Hospital,Lanzhou 730000,China;Department of Function,Gansu Provincial Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃省人民医院皮肤科,甘肃兰州730000 [2]甘肃省人民医院功能科,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2020年第4期86-89,共4页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金资助项目(18JR3RA056)。

摘　　要：目的评价白芍总苷治疗老年中重度斑块状银屑病的疗效和安全性。方法将纳入的63例老年中重度斑块状银屑病患者随机分为2组,对照组给予外用药物治疗,试验组在外用药物治疗的基础上给予白芍总苷口服,于治疗前和治疗8、12周后分析银屑病面积和严重程度指数(PASI)、皮肤病生活质量指数(DLQI)及简明健康状况量表(SF-36)评分变化。结果 2组患者在治疗8、12周后PASI、DLQI评分均低于治疗前,SF-36评分高于治疗前(P <0.05),且治疗组患者PASI、DLQI评分均低于对照组,SF-36评分高于对照组(P <0.05),Pearson线性相关性显示PASI评分与DLQI评分呈正相关关系(P <0.05)。结论白芍总苷治疗老年中重度斑块状银屑病效果好,不良反应少,DLQI评分与病情严重程度相关。Objective To evaluate the efficacy and safety of total glucosides of paeony(TGP)in the treatment of moderate to severe plaque psoriasis in the elderly. Methods Sixty-three cases of moderate to severe plaque psoriasis of the elderly were randomly divided into the experiment group and the control group, the experiment group was treated with TGP combined with topical drugs, while the control group was treated with topical drugs alone. The levels of psoriasis area and severity index(PASI), dermatology life quality index(DLQI)and generic 36-item short-form(SF-36) scores and adverse reactions were compared between the two groups before the treatment and 8 and 12 weeks after the treatment. Results The levels of PASI and DLQI scores of 8 and 12 weeks after the treatment were lower than those before the treatment, in the experiment group were significantly lower than those in the control group(P < 0.05), while the levels of SF-36 scores of8 and 12 weeks after the treatment were higher than those before the treatment, in the experiment group were significantly higher than those in the control group, the difference were both statistically significant(P < 0.05), Pearson correlation analysis showed that there were obviously positive correlation between PASI and DLQI(P < 0.05). Conclusion The clinical application of TGP after treatment is better, the low rate of adverse reactions, while DLQI scores were correlated with severity of the disease.

关 键 词：白芍总苷 斑块状银屑病 疗效 安全性 

分 类 号：R593.22[医药卫生—内科学]