右美托咪定与丙泊酚在宫腔镜输卵管通液术中的效果比较  

Comparison of Dexmedetomidine and Propofol in hysteroscopic hydrotubation

作　　者：杨文 刘松[2] 赵汝有[2] 崔新亮[2] 胡俊[2] 金哲 Yang Wen;Liu Song;Zhao Ruyou;Cui Xinliang;Hu Jun;Jin Zhe(Department of Anesthesiology,Taikang Xianlin Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School,Nanjing,Jiangsu 210046,China;Department of Anesthesiology,No.2 Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233040,China)

机构地区：[1]南京泰康仙林鼓楼医院麻醉科,苏南京210046 [2]蚌埠医学院第二附属医院麻醉科,徽蚌埠23040

出　　处：《医药前沿》2020年第15期48-50,共3页Journal of Frontiers of Medicine

摘　　要：目的:比较右美托咪定与丙泊酚在宫腔镜输卵管通液术中的应用效果。方法:选择于2015年3月—2017年10月拟行宫腔镜输卵管通液术的患者78例,随机分为右美托咪定组(A组)和丙泊酚组(B组),各39例,两组先静脉泵入舒芬太尼0.2ug/kg,A组同时静脉泵入右美托咪定(1.0ug/kg 15min,后1.0ug/kg·h维持),B组同时静脉泵入丙泊酚5mg/kg·h,手术前静脉推注1.5mg/kg。观察指尖氧饱和度、平均动脉压、苏醒时间、离开复苏室时间、满意度。结果:在麻醉后(t1)、输卵管插管时(t3、t4)、手术结束(t5)各时刻A组指尖氧饱和度、平均动脉压、显著高于B组;苏醒时间、离开时间显著短于B组(P<0.05)。A组呼吸抑制、循环抑制发生率低于B组,差异显著(P<0.05)。两组术中体动发生率无显著差异(P>0.05),但手术医生满意度有显著差异(P<0.05)。结论:右美托咪定在宫腔镜输卵管通液术中效果优于丙泊酚,且对呼吸、循环抑制率低,可提高安全性。Objective To compare the effects of Dexmedetomidine and Propofol in hysteroscopic hydrotubation.Methods From March 2015 to October 2017,A total of 78 patients undergoing hysteroscopic hydrotubation were randomly divided into Dexmedetomidine group(group A,39 cases)and Propofol group(group B,39 cases)according to sequential coding.All patients were sequentially injected sufentanil(0.2ug/kg)intravenously.In group A,1.0ug/kg dexmedetomidine was infused in 15 minutes simultaneously and then maintained 1.0ug/kg·h.In group B,propofol was infused at the rate of 5mg/kg·h simultaneously and 1.5mg/kg propofol was added intravenously before operation.Pulse oxygen saturation(SpO2),mean arterial pressure(MAP),the time of recovery and discharge,satisfaction of surgeon were observed.Results There were significant statistical difference on incidence of respiratory(6 patients in group A and 15 patients in group B)and circulation(8 patients in group A and 17 patients in group B)depression(P<0.05).The value of SpO2,MAP in group A were significantly higher than those in group B(P<0.05),and the time of recovery and discharge in group B were also significantly shorter than those in group B(P<0.05).There was no significant statistical difference on incidence of body moving(P<0.05),but there was significant statistical difference on satisfaction of surgeon(P<0.05).Conclusion Comparing to propofol,dexmedetomidine may decrease the incidence of respiratory and circulation depression and can improve the safety during hysteroscopic hydrotubation.

关 键 词：右美托咪定 丙泊酚 输卵管通液术 

分 类 号：R713[医药卫生—妇产科学]