基于微流控芯片荧光成像检测仪研制  

Research and fabrication of fluorescence imaging detector based on micro-flow control chip

作　　者：杨海涛 刘桂礼[1] 孔全存[1] 李东[1,2] YANG Haitao;LIU Guili;KONG Quancun;LI Dong(School of Instrumentation Science and Opto-Electronics Engineering,Beijing Information Science and Technology University,Beijing 100192,China;Beijing Key Laboratory(Measurement and Control of Mechanical and Electrical System),Beijing Information Science and Technology University,Beijing 100192,China)

机构地区：[1]北京信息科技大学仪器科学与光电工程学院,北京100192 [2]北京信息科技大学北京市重点实验室(机电系统测控),北京100192

出　　处：《传感器与微系统》2020年第9期77-79,83,共4页Transducer and Microsystem Technologies

基　　金：国家自然科学基金资助项目(51675054);北京市自然科学基金资助项目(3172013);北京市教委科技发展计划面上资助项目(KM201711232005);北京市重点实验室(机电系统测控)开放资助项目(5221735107)。

摘　　要：针对激光诱导荧光检测系统结构体积大、成本高且不利于推广应用的缺点,提出以共聚焦光路结构成像原理为基础,将LED作为激发光源并结合Zemax光学设计优化光路结构尺寸。在降低系统成本的同时达到了使其结构更加紧凑、体积较小的设计效果。同时减小了激发光能量在结构中的损失,有效地提高了系统的信噪比,顺应了POCT医疗仪器小型化、低成本、便携式的发展趋势。Aiming at the shortcoming that the structure of laser induced fluorescence detection system is large in volume,high in cost and not conducive to popularization and application,optimize the structure size of optical path based on the principle of confocal optical path structure imaging is proposed,using LED as excitation light source combined with Zemax optical design.While reducing the cost of the system,the design effect of making its structure more compact and smaller is achieved.At the same time,the loss of excitation light energy in the structure is reduced,the signal-to-noise ratio of the system is improved effectively,and the development trend of miniaturization,low cost and portable of point-of-care testing(POCT)medical instrument is complied with.

关 键 词：荧光检测系统 共聚焦光路 LED激发光源 Zemax光路优化 

分 类 号：TP216.6[自动化与计算机技术—检测技术与自动化装置] TP212[自动化与计算机技术—控制科学与工程]