某医院ICU鲍曼不动杆菌感染的耐药性及抗菌药物使用临床研究  

Clinical study on drug resistance and antimicrobial use of acinetobacter baumannii infection in ICU

作　　者：王玉巧[1] 王萍 何琼 杨腊梅 刘莉 田娟 田超 尤汉萍[1] 高小芳 WANG Yuqiao;WANG Ping;HE Qiong;YANG Lamei;LIU Li;TIAN Juan;TIAN Chao;YOU Hanping;GAO Xiaofang(Department of ICU,Ningxia Hui Autonomous Region People’s Hospital,Yinchuan 750002,China)

机构地区：[1]宁夏回族自治区人民医院ICU,宁夏银川750002

出　　处：《宁夏医学杂志》2020年第8期742-744,共3页Ningxia Medical Journal

基　　金：宁夏回族自治区自然科学基金项目(2019AAC03304);宁夏回族自治区人民医院培育振兴项目(201821)。

摘　　要：目的分析鲍曼不动杆菌感染的分布特征、耐药性及与临床抗菌药物使用强度的相关性。方法选取重症医学科收住的感染患者为研究对象,采集患者不同部位标本进行细菌培养,了解鲍曼不动杆菌细菌标本来源的分布情况,进行药物敏感分析试验,同时分析患者抗菌药物使用强度和耐药性的相关关系。结果 2016年、2017年及2018年分别检出检出鲍曼不动杆菌为125、112及101株,共338株鲍曼不动杆菌培养阳性标本,标本来源主要为呼吸道分泌物;采取严格院感措施后,鲍曼不动杆菌临床分离株有减少趋势;鲍曼不动杆菌对多种抗生素均有不同程度的耐药,且系多重耐药;头孢他啶、亚胺培南的使用强度与鲍曼不动杆菌的耐药率呈正相关性(P<0.05)。结论院内鲍曼不动杆菌临床分离菌株分布广泛,多重耐药明显,抗生素选择需要联合用药,加强院感是减少鲍曼不动杆菌感染的有效措施。Objective To analyze the distribution characteristics,drug resistance of acinetobacter baumannii infection specimens and the correlation between drug resistance and the intensity of clinical antimicrobial use.Methods Patients admitted to the department of intensive care medicine in our hospital for nearly 3 years were selected.After admission,The samples from different parts of the patients were collected for bacterial culture.The source and distribution of Acinetobacter baumannii were understood,and the drug sensitivity analysis test was conducted.At the same time,the correlation between the use intensity of antibiotics and drug resistance was analyzed.Results In 2016,2017 and 2018,125,112 and 101 strains of acinetobacter baumannii were detected,and a total of 338 cases of acinetobacter baumannii were cultured positive samples,the lower samples were mainly from respiratory secretions.After taking strict hospital infection measures,the clinical isolates of Acinetobacter baumannii had a decreasing trend.Acinetobacter baumannii was a multidrug-resistant bacterium with varying degrees of resistance to various antibiotics.The intensity of use of ceftazidine and imipenem was positively correlated with drug resistance rate of acinetobacter baumannii(P<0.05).Conclusion The clinical isolates of acinetobacter baumannii are widely distributed in the hospitals,and the multiple drug resistance is obvious.The choice of antibiotics should be combined with medicine,and strengthening the sense of hospital is an effective measure to reduce the infection of acinetobacter baumannii.

关 键 词：鲍曼不动杆菌 耐药性 抗菌药物 

分 类 号：R378[医药卫生—病原生物学]