从阳虚论治奥沙利铂所致中毒性周围神经病  

Treating Oxaliplatin-Induced Toxic Neuropathy based on Yang Deficiency

作　　者：张传龙[1] 谭兆峰 齐元富[2] ZHANG Chuanlong;TAN Zhaofeng;QI Yuanfu(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院,山东济南250014

出　　处：《山东中医杂志》2020年第9期918-921,共4页Shandong Journal of Traditional Chinese Medicine

基　　金：山东省保健科技协会科学技术课题(编号:SDBJKT20180119)。

摘　　要：奥沙利铂作为第三代铂类化疗药物,具有良好的临床疗效,但其导致的中毒性周围神经病限制了它的应用。从中医角度分析,奥沙利铂所致中毒性周围神经病的核心病机为阳虚,且主要责于脾阳虚。治疗上应治病求本,以固护脾胃为先,扶正祛邪,祛湿消滞顺脾性;同时注重内外合治、中西医结合。Oxaliplatin,the third generation of platinum-based chemotherapy drugs,has good clinical efficacy,but its application is limited by the toxic neuropathy caused by it. Based on the theory of traditional Chinese medicine(TCM),the core disease mechanism of the oxaliplatin-induced toxic neuropathy is yang deficiency,mainly involving spleen yang deficiency. The treatment should aim at the root cause,and therefore to protect the spleen and stomach is the most important. Also,tonifying healthy qi and removing pathogen should be performed through dispelling dampness and dispersing stagnation to invigorate spleen.Besides,the internal and external should be treated simultaneously and western medicine and TCM should be combined.

关 键 词：阳虚 脾阳虚 奥沙利铂 中毒性周围神经病 固护脾胃 祛湿消滞 化疗 

分 类 号：R273.05[医药卫生—中西医结合]