睡眠药物发展简史  

Brief History of Sleep Drug Development

作　　者：章彬佳 邱子梁 张杰 ZHANG Binjia;QIU Ziliang;ZHANG Jie(Shanghai Haitian Pharmaceutical Technology Development Co.,Ltd.,Shanghai 200032,China)

机构地区：[1]上海海天医药科技开发有限公司,上海610000

出　　处：《世界睡眠医学杂志》2020年第7期1169-1173,共5页World Journal of Sleep Medicine

摘　　要：良好的睡眠对人体健康至关重要,而遗传因素、环境刺激、疾病和药物等都会破坏睡眠-觉醒结构,导致睡眠障碍。近年来,随着社会的发展,生活压力逐渐加大,失眠的发病率呈上升并呈年轻化趋势。本文主要从促进睡眠的角度来简述睡眠药物发展的历史及当前研发聚焦的靶点,以助临床更好地了解镇静催眠药物并合理使用。Good sleep is critical for human health.However,numerous factors will disturb the sleep-wake profile,such as heredity,environmental stimulus,diseases&drugs and so on,ultimately leading to sleep disorder.Too much sleep and lack of sleep are two main clinical manifestations,and the insomnia incidence is rising and shows younger trend with the development of society in recent years.We will briefly introduce the history of sleep-promoting medicine and the current targets for research and discovery,in order to help people know more about hypnotics and use them more rationally.

关 键 词：睡眠 药物发展 药物研发 

分 类 号：R338.63[医药卫生—人体生理学] R971.3[医药卫生—基础医学]