妊娠期肝内胆汁淤积症孕妇凝血功能及妊娠结局的变化  被引量:5

Clinical Study on Coagulation Function and Pregnancy Outcome of Intrahepatic Cholestasis of Pregnancy

在线阅读下载全文

作  者:陈小芸 李建华[1] 胡继芬[1] Chen Xiaoyun;Li Jianhua;Hu Jifen(The First Affiliated Hospital of Fujian Medical University,Fuzhou Fujian 350005,China)

机构地区:[1]福建医科大学附属第一医院,福建福州350005

出  处:《医疗装备》2020年第15期47-49,共3页Medical Equipment

基  金:福建省科技厅课题(2017Y0034)。

摘  要:目的探讨妊娠期肝内胆汁淤积症(ICP)孕妇凝血功能及妊娠结局的变化。方法选择2017年1月至2019年12月在福建医科大学附属第一医院产科住院分娩的92例ICP孕妇作为病例组,并将其分为重度ICP组(23例)和轻度ICP组(69例)两亚组,以系统随机抽样法选取同期在福建医科大学附属第一医院产科住院分娩的105名自然受孕健康孕妇作为对照组,采用单因素分析3组凝血功能指标、血小板相关指标及围生儿不良结局发生率的差异。结果重度ICP组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、国际标准化比值(INR)均高于对照组和轻度ICP组(P<0.05);重度ICP组的平均血小板内容物浓度(MPC)低于对照组(P<0.05);重度ICP组新生儿窒息发生率高于对照组(P<0.05);重度ICP组和轻度ICP组早产儿发生率均高于对照组(P<0.05);重度ICP组早产儿发生率高于轻度ICP组(P<0.05)。结论重度ICP孕妇凝血功能改变明显,易导致产后出血,增加围生儿不良结局的发生风险,临床需高度重视,于围生期给予积极干预,以显著改善ICP孕妇的妊娠结局。Objective To investigate the changes of coagulation function and pregnancy outcome in intrahepatic cholestasis of pregnancy(ICP).Methods 92 ICP patients who gave birth in the hospital from January 2017 to December 2019 were selected as the case group(23 in the severe ICP group and 69 in the mild ICP group).A total of 105 healthy pregnant women who conceived naturally and delivered during the same period were selected as the control group by systematic random sampling.The difference was analyzed in the three groups from three aspects:coagulation function indexes,platelet indexes and perinatal outcome incidence through univariate analysis.Results PT,APTT and INR in severe ICP group were significantly higher than those in control group and mild group(P<0.05).MPC level in severe ICP group was lower than that in control group(P<0.05).The rate of neonatal asphyxia in severe ICP group was higher than that in control group(P<0.05).The incidence of premature infants in severe ICP group and mild ICP group was significantly higher than that in control group(P<0.05),and that in severe ICP group was higher than that in mild ICP group(P<0.05).Conclusion Pregnant women with severe ICP have obvious changes in blood coagulation function,which can easily lead to postpartum hemorrhage and increase the incidence of adverse perinatal outcomes.Therefore,in clinic,we should pay great attention to it,treat it actively and improve pregnancy outcomes of ICP pregnant women.

关 键 词:妊娠期肝内胆汁淤积症 凝血功能 妊娠结局 

分 类 号:R714.7[医药卫生—妇产科学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象