GnRH-a延长给药间隔周期治疗子宫内膜异位症的临床研究  

Clinical study on treatment of endometriosiswith extended administration interval of GnRH-a

作　　者：温芯 黄勇[1] 黄叶芳[2] 杨炜婷 张瑜[1] WEN Xin;HUANG Yong;HUANG Yefang;YANG Weiting;ZHANG Yu(The First People's Hospital of Liangshan Yi Autonomous Prefecture,Xichang 615000,Sichuan,China;The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]凉山彝族自治州第一人民医院,四川西昌615000 [2]成都中医药大学附属医院,四川成都610075

出　　处：《西部医学》2020年第8期1219-1223,共5页Medical Journal of West China

基　　金：凉山州科知局科研课题(18YYJS0079)。

摘　　要：目的探讨GnRH-a延长给药间隔周期治疗子宫内膜异位症患者对临床疗效的影响。方法选取2017年9月~2018年9月凉山彝族自治州第一人民医院和成都中医药大学附属医院进行子宫内膜异位症治疗的114例患者为研究对象,随机分为常规组与延长组,每组57例。两组患者均采用曲普瑞林治疗,常规组给药间隔为4周,延长组给药间隔为6周。比较两组患者治疗前后痛经程度、子宫体积、血清性激素水平及治疗后月经恢复时间、总有效率、并发症及复发情况。结果治疗后,延长组患者痛经程度、子宫体积显著优于常规组(均P<0.05);两组患者LH、FSH及E 2水平显著降低,但两组无显著差异(P>0.05)。治疗后,延长组患者月经恢复时间显著优于常规组(P<0.05);延长组与常规组治疗总有效率分别为89.47%及91.23%,两组无显著差异(P>0.05);延长组患者各项并发症发生几率显著低于常规组(均P<0.05)。随访1年,两组患者复发情况无显著差异(P>0.05)。结论GnRH-a延长给药时间间隔、减少给药次数治疗治疗子宫内膜异位症,患者不良反应明显减少,复发率降低,临床有效率无明显降低,且能减少患者治疗费用,可在临床推广应用。Objective To study the effect of prolonging the interval of GnRH-a administration on the clinical efficacy of treating endometriosis patients.Methods From September 2017 to September 2018,114 patients treated with endometriosis at the First People's Hospital of Liangshan Yi Autonomous Prefecture and the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine were selected as the survey subjects,and randomly divided into routine group and extended group.Each of the 57 patients was treated with triptorelin.The interval between the conventional group was 4 weeks and that between the extended group was 6 weeks.The dysmenorrhea,uterine volume,serum sex hormone levels,menstrual recovery time,total effective rate,and complications and recurrence of the two groups of patients were compared before and after treatment.Results The dysmenorrhea and uterine volume of the patients in the extension group were significantly better than those in the conventional group(P<0.05).The levels of LH,FSH,and E2 in the two groups were significantly reduced after treatment,but there were no significant differences in the two indicators between the two groups(P>0.05).The menstrual recovery time of patients in the extension group was significantly better than that in the conventional group(P<0.05).The total effective rates of treatment in the extension group and the conventional group were 89.47%and 91.23%,respectively,and there was no significant difference between the two groups(P>0.05).The incidence of various complications in patients was significantly lower than that in the conventional group(P<0.05).After one year follow-up,there was no significant difference in recurrence between the two groups(P>0.05).Conclusion Patients with endometriosis should be treated with Gn RH-a for extended interval intervals.On the basis of ensuring effective treatment,they can further alleviate dysmenorrhea and reduce uterine size,reduce serum sex hormone levels,extend the period of menstrual recovery and reduce the occurrence of complica

关 键 词：GNRH-A 给药间隔周期 子宫内膜异位症 临床疗效 

分 类 号：R711.71[医药卫生—妇产科学]