无肝素抗凝连续血液净化治疗脓毒血症的应用及预后分析  

Application and prognosis of continuous blood purification without heparin in the treatment of sepsis

作　　者：赖杨骁 方强[1] Lai Yangxiao;Fang Qiang(Intensive Care Unit,the First Affiliated Hospital of Zhejiang University Medical College,Hangzhou,Zhejiang 310003,China)

机构地区：[1]浙江大学医学院附属第一医院重症监护室,浙江杭州310003

出　　处：《医药前沿》2020年第16期18-19,共2页Journal of Frontiers of Medicine

摘　　要：目的:探讨无肝素抗凝连续血液净化治疗脓毒血症的应用及预后。方法:选择我院150例2017年1月-2019年1月脓毒血症患者。随机分组,对照组实施低分子肝素或者枸橼酸钠抗凝连续血液净化治疗,无肝素抗凝组则实施无肝素抗凝连续血液净化治疗。比较两组脓毒血症疗效;白细胞计数、血小板计数恢复正常的时间、住院的时间;治疗前后患者平均肌酐值、APACHEII评分。结果:无肝素抗凝组脓毒血症疗效、白细胞计数、血小板计数恢复正常的时间、住院的时间、平均肌酐值、APACHEII评分显著优于对照组(P<0.05)。结论:无肝素抗凝连续血液净化治疗脓毒血症效果确切,可有效控制机体炎症,更好改善肾功能,值得应用。Objective To explore the application and prognosis of continuous blood purification without heparin in the treatment of sepsis.Methods 175 cases of sepsis in our hospital from January 2017 to January 2019 were selected.The control group was randomly assigned to receive continuous blood purification therapy with low molecular weight heparin or sodium citrate anticoagulation,while the non-heparin group received continuous blood purification therapy with non-heparin anticoagulation.The efficacy of sepsis was compared between the two groups.White blood cell count,platelet count back to normal time,hospital stay time;Mean creatinine and APACHEII score before and after treatment.Results Compared with the control group,the efficacy of sepsis in the heparin-free anticoagulant group,the time of white blood cell count and platelet count returning to normal,the time of hospitalization,mean creatinine value and APACHEII score were better(P<0.05).Conclusion Continuous blood purification without heparin has a definite effect in treating sepsis,which can effectively control inflammation in the body and improve renal function.

关 键 词：无肝素抗凝连续血液净化 脓毒血症 应用及预后 

分 类 号：R457[医药卫生—治疗学]