环磷酰胺冲击疗法治疗难治性肾病综合征的临床疗效分析  

Clinical effect analysis of cyclophosphamide shock therapy on refractory nephrotic syndrome

作　　者：张希燕 王海成 赵玉先 Zhang Xiyan;Wang Haicheng;Zhao Yuxian(Department of Nephrology,Linyi Central Hospital,Linyi,Shandong 276400,China)

机构地区：[1]临沂市中心医院肾内科一病区,山东临沂276400

出　　处：《医药前沿》2020年第16期21-22,共2页Journal of Frontiers of Medicine

摘　　要：目的:分析在治疗难治性肾病综合征疾病中应用环磷酰胺冲击疗法的临床效果。方法:利用随机分组对我院在2017年2月-2019年5月收治的40例患者,其中对比组患者(n=20)行常规治疗,研究组患者(n=20)在对比组治疗基础上行环磷酰胺冲击疗法治疗,对比两组患者最终治疗效果。结果:研究组患者治疗后并发症发生概率10%低于对比组患者治疗后并发症发生概率的45%,差异有统计学意义(P<0.05);研究组治疗总有效率90%高于对比组治疗总有效率的50%,差异有统计学意义(P<0.05)。结论:在治疗难治性肾病综合征疾病中应用环磷酰胺冲击疗法的临床效果显著,故值得在临床中使用。Objective To analyze the clinical effect of cyclophosphamide shock therapy in the treatment of refractory nephrotic syndrome.Methods A randomized study was conducted on 40 patients admitted to our hospital from February 2017 to May 2019.Patients in the comparison group(n=20)received conventional treatment,while patients in the study group(n=20)received shock therapy based on treatment in the comparison group,and the final treatment effect was compared between the two groups.Results The incidence of complications in the study group was 10%lower than that in the comparison group(45%),P<0.05 was statistically significant.The effective rate of the final treatment in the study group was 90%higher than that in the control group(50%),P<0.05 was statistically significant.Conclusion Cyclophosphamide shock therapy is effective in the treatment of refractory nephrotic syndrome.

关 键 词：环磷酰胺冲击疗法 难治性肾病综合征 并发症 

分 类 号：R692[医药卫生—泌尿科学]