高粱根中1个新大环酚苷  

A new macrocyclic phenolic glycoside from Sorghum vulgare root

作　　者：王山立 周浪 朱安祥[2,3] 杨小生 李齐激 杨娟 WANG Shan-li;ZHOU Lang;ZHU An-xiang;YANG Xiao-sheng;LI Qi-ji;YANG Juan(Pharmaceutical College,Guizhou University,Guiyang 550002,China;State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550014,China;the Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences、Guiyang 550014,China)

机构地区：[1]贵州大学药学院,贵州贵阳550002 [2]贵州医科大学省部共建药用植物功效与利用国家重点实验室,贵州贵阳550014 [3]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550014

出　　处：《中国中药杂志》2020年第15期3689-3693,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81860693)。

摘　　要：运用硅胶柱色谱、MCI凝胶柱色谱和制备型HPLC等色谱技术从高粱根提取物中分离纯化得到11个化合物,并通过NMR和MS波谱技术鉴定其结构为4-[(6′-O-β-D-吡喃葡萄糖)氧基]羟基苯乙酸环二聚内酯(1)、β-谷甾醇(2)、豆甾醇(3)、胡萝卜苷(4)、对甲氧基肉桂酸(5)、紫杉氰糖苷(6)、绿原酸(7)、对羟基苯甲醛(8)、琥珀酸(9)、反式对羟基肉桂酸(10)、obtusalin(11)。化合物4,5,9~11为首次从高粱中分离得到,化合物1为首次发现的以对羟基苯乙酸酯葡萄糖苷反向聚合形成的拥有24环的二聚双内酯酚苷,命名为sorgholide A。Eleven compounds were isolated and purified from Sorghum vulgare root extract, through column chromatography over silica gel, MCI gel, and preparative HPLC. Their structures were established by MS, 1 D NMR and 2 D NMR data as sorgholide A(1), β-sitosterol(2), stigmastero(3), daucosterol(4), 4-methoxycinnamic acid(5), taxiphyllin(6), chlorogenic acid(7), p-hydroxybenzaldehyde(8), succini acid(9), trans-p-hydroxycinnamic acid(10), obtusalin(11). Compounds 4,5 and 9-11 were reported from this species for the first time, and compound 1 is the first 24 ring dimeric double lactonol glycoside formed by reverse polymerization of p-hydroxyphenylacetate glucoside, named sorgholide A.

关 键 词：高粱根 化学成分 二聚双内酯酚苷 

分 类 号：R284.1[医药卫生—中药学]