静电纺丝小口径人工血管支架材料的制备及其抗凝血性能的初步评价  

Preliminary Evaluation on the Construction of Small-diameter Artificial Blood Vessels with Anticoagulant Properties by Blending and Coaxial Electro-spinning

作　　者：石欣 田婧玮 王晰 朱莉娥 邓小旋 李鑫 安军[1] Shi Xin;Tian Jingwei;Wang Xi;Zhu Lie;Deng Xiaoxuan;Li Xin;An Jun(College of Life Sciences,Nankai University,Tianjin 300071,China;TEDA International Cardiovascular Hospital,Tianjin 300457,China)

机构地区：[1]南开大学生命科学学院,天津300071 [2]泰达国际心血管病医院,天津300457

出　　处：《南开大学学报（自然科学版）》2020年第4期67-74,共8页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：南开大学第十五届本科生创新科研"百项工程"项目(BX15260);南开大学第十七届本科生创新科研"百项工程"项目(201910055797);天津市滨海新区卫生健康委员会重点支持科技项目(2017BWKZ008)。

摘　　要：首先合成催化体内一氧化氮供体(RSNO)释放一氧化氮(NO)的铜离子络合物(Cu(Ⅱ)-DTTCT),然后以Cu(Ⅱ)-DTTCT和具有良好生物相容性的高分子聚合物—聚己内酯(PCL)为原材料,利用静电纺丝技术制备小口径人工血管支架材料.结果表明,采用物理共混方式制备的支架材料尽管具有良好的催化性能,但存在突释现象和不同程度的细胞毒性.为了解决这一问题,选取较低细胞毒性的催化剂用量,以同轴电纺方式制备出以催化剂Cu(Ⅱ)-DTTCT和PCL为芯,以PCL为壳的具有芯壳结构的小口径人工血管支架材料,并对它的抗凝血性能进行了初步评价.这种芯壳结构支架材料在一定程度上能够控制NO释放速率,很好地解决了突释现象,并且不具有明显的细胞毒性.A copper ion complex(Cu(Ⅱ)-DTTCT) is synthesized, which can catalyze the release of NO from nitric oxide donor(RSNO). The small-diameter vascular grafts were fabricated by electrospinning with the use of Cu(Ⅱ)-DTTCT and highly degradable high-molecular polymer poly(ε-caprolactone,PCL).The results showed that although the materials prepared by blending had good catalytic performance, there were burst release and different degrees of toxicity. In order to solve the problem, coaxial electro-spinning technique was used to synthesize small-diameter vascular graft materials, in which Cu(Ⅱ)-DTTCT and PCL is the core and PCL is the shell. From the results of preliminary evaluation of its performance, the core-shell vascular crafts can slow the release of NO to some extent with small toxicity.

关 键 词：小口径人工血管 静电纺丝 NO 

分 类 号：O631.4[理学—高分子化学]