中性粒细胞活化导致血管内皮功能损伤在子痫前期发病中的作用研究进展  

Advances in the Role of Neutrophil Activation in Vascular Endothelial Function Damage in the Pathogenesis of Pre-Eclampsia

作　　者：徐振华 马廷学[1] 王永红(审校)[1] XU Zhen-hua;MA Ting-xue;WANG Yong-hong(Department of Obstetrics and Gynecology,The Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院妇产科,太原030001

出　　处：《国际妇产科学杂志》2020年第4期365-368,共4页Journal of International Obstetrics and Gynecology

基　　金：山西省面上自然基金项目(201901D111367);山西省卫健委科研计划课题(2019050);山西医科大学校级博士启动基金项目(BS201713)。

摘　　要：子痫前期(PE)是妊娠中晚期特有的多基因、多系统损害性疾病,若病情进展严重,可导致胎盘早剥、弥漫性血管内凝血(DIC)、子痫、HELLP综合征等并发症的发生,是全球孕产妇及新生儿发病率和死亡率升高的主要原因。因PE病情变化呈动态性进展,且临床表现多样化,故治疗原则以解痉、降压、镇静等为主,适时终止妊娠是最有效的临床治疗措施。目前其病因学研究尚存争议,多数研究表明妊娠期间免疫和激素反应导致的血管内皮功能损伤是PE的主要病理生理学改变。其中中性粒细胞活化后引起的炎症级联反应在PE发生和发展中发挥重要作用。现就中性粒细胞活化导致血管内皮功能损伤在PE发病中作用的研究进展进行综述。Pre-eclampsia(PE)is a polygenic and multi-system damaging disease unique to the second and third trimester of pregnancy.If the disease progresses severely,it can lead to complications such as placental abruption,diffuse intravascular coagulation(DIC),eclampsia,and HELLP syndrome.It is the main cause of rising maternal and neonatal morbidity and mortality worldwide.Due to the dynamic progress of PE,and the clinical manifestations are diversified,the principle of treatment is mainly antispasmodic,antihypertensive,sedative and so on.The timely termination of pregnancy is the most effective clinical treatment.At present,studies on its etiology are still controversial.Most studies show that vascular endothelial function damage caused by immune and hormone response during pregnancy is the main pathophysiological change of PE.Among them,the inflammatory cascade caused by neutrophil activation plays an important role in the occurrence and development of PE.This article reviews the research progress on the role of neutrophil activation in vascular endothelial function damage in the pathogenesis of PE.

关 键 词：先兆子痫 中性粒细胞 血管内皮功能损伤 内皮 血管 

分 类 号：R714.244[医药卫生—妇产科学]