卵巢不典型子宫内膜异位症恶变机制的研究进展  

Research Progress on Malignant Mechanism of Atypical Ovarian Endometriosis

作　　者：王雪[1] 史巧瑞 王晓慧(审校)[1] WANG Xue;SHI Qiao-rui;WANG Xiao-hui(First Clinical Medical College of Lanzhou University,Department of Obstetrics and Gynecology,Lanzhou University First Hospital,Ganzhou Provincial Key Laboratory of Gynecologic Oncology,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州大学第一医院妇产科,甘肃省妇科肿瘤重点实验室,730000

出　　处：《国际妇产科学杂志》2020年第4期433-436,442,共5页Journal of International Obstetrics and Gynecology

摘　　要：子宫内膜异位症(endometriosis,EMs)指子宫内膜组织出现在子宫体以外的部位,以卵巢、宫骶韧带最常见。卵巢不典型子宫内膜异位症(atypical endometriosis,aEM)指异位于卵巢的子宫内膜腺体呈异型性,其组织学呈现出“交界性”或“过渡状态”,属于癌前病变。卵巢aEM与子宫内膜异位症相关性卵巢癌(endometriosis associated ovarian cancer,EAOC)的发生、发展密切相关,但其严重程度未能得到足够重视,使该疾病在临床上容易漏诊。现就卵巢aEM恶变相关机制的研究进展做一阐述,希望提高临床医师对卵巢aEM的认识。Endometriosis(EMs)refers to the appearance of endometrial tissue outside the uterine body,with the ovaries and uterine ligaments being the most common.Atypical endometriosis(aEM)refers to the abnormal shape of endometrial glands that are located in the ovary,and its histology appears to be"borderline"or"transitional",which is a precancerous lesion.aEM is closely related to the occurrence and development of endometriosis associated ovarian cancer(EAOC),but its severity has not been paid enough attention,which makes the disease easily missed in clinical diagnosis.The research progress of the mechanism of ovarian aEM malignant transformation is described here,hoping to improve the clinician′s understanding of ovarian aEM and bring some help to clinical work.

关 键 词：子宫内膜异位症 子宫内膜增生 卵巢肿瘤 基因 治疗 

分 类 号：R711.71[医药卫生—妇产科学]