基于足细胞损伤探讨益气补肾固涩药对蛋白尿的作用及其机制  

Function and Mechanism of Yiqi Bushen Guse Drugs on Proteinuria Based on Study of Podocyte Damage

作　　者：王娟 刘蕊 韩世盛[3] 陈敏[3] Wang Juan;Liu Rui;Han Shisheng;Chen Min(Department of Anning,Chengjiaqiao Street Community Health Service Center.Shanghai 201103,China;Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310005,China;Department of Nephrology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海市长宁区程家桥街道社区卫生服务中心,上海201103 [2]浙江中医药大学附属第二医院,浙江杭州310005 [3]上海中医药大学附属岳阳中西医结合医院肾内科,上海200437

出　　处：《亚太传统医药》2020年第8期189-193,共5页Asia-Pacific Traditional Medicine

基　　金：上海市科委医学引导类项目(15401930800)。

摘　　要：蛋白尿是慢性肾脏病的主要临床表现之一,亦是疾病进展的独立危险因素。各种原因造成的足细胞损伤致使肾小球滤过屏障受损是蛋白尿产生的主要原因。临床上应用益气补肾固涩药治疗蛋白尿的疗效已较为确切,其机理有待进一步研究证实。从足细胞损伤角度探讨益气补肾固涩药对蛋白尿的作用及其机制。Proteinuria is one of the main clinical manifestations of chronic kidney disease and an independent risk factor for disease progression.Damage to the glomerular filtration barrier caused by podocyte damage caused by various causes is the main cause of proteinuria.The clinical application of Yiqi Bushen Guse druds in the treatment of proteinuria has been more precise,but its mechanism needs further research.This article will discuss the effect of Yiqi Bushen Guse druds on proteinuria and its mechanism from the perspective of podocyte injury.

关 键 词：蛋白尿 足细胞损伤 益气补肾固涩药 作用机制 

分 类 号：R256.5[医药卫生—中医内科学]