健康行为管理对慢性阻塞性肺疾病患者炎性水平的影响及与急性加重的相关性分析  

Effects of health behavior management on inflammation levels in patients with chronic obstructive pulmonary disease and its correlation with acute exacerbation

作　　者：武思羽 宋贝贝[2] 敬增 叶丽云[2] 曹敬[2] 王正 周广伟[1] 李静[1] 刘新秀[1] 孟爱宏[1] WU Siyu;SONG Beibei;JING Zeng(Department of Respiratory and Critical Care Medicine,The Second Hospital of Hebei Medical University,Hebei,Shijiazhuang 050000,China;不详)

机构地区：[1]河北医科大学第二医院呼吸与危重症三科,石家庄市050000 [2]河北医科大学第二医院呼吸与危重症一科,石家庄市050000 [3]河北省石家庄市第四医院药剂科

出　　处：《河北医药》2020年第16期2478-2482,共5页Hebei Medical Journal

基　　金：河北省医学科学研究重点课题(编号:20180351)。

摘　　要：目的探讨健康行为管理对慢性阻塞性肺疾病(COPD)患者炎症水平的影响及与急性加重的相关性分析。方法选取2015年1月至2017年1月就诊的120例COPD患者纳入本研究,按随机数字表法分为健康管理组和常规治疗组,每组60例,2组患者均进行常规治疗,健康管理组在此基础上增加健康行为管理干预。另选同期进行健康体检的健康志愿者50例为健康对照组。对3组患者及健康对照组受试者的炎性因子水平进行检测对比,并对健康管理组和常规治疗组在治疗期间急性加重的发生次数进行对比。采用Pearson检验对COPD患者的炎性因子水平与急性加重发生次数的相关性进行探讨分析。结果治疗后健康管理组患者、常规治疗组患者的炎性因子包括C-反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均高于对照组,健康管理组患者的各项指标均低于常规治疗组,3组间比较差异有统计学意义(P<0.05)。健康管理组患者的急性加重的发生次数、住院次数、平均住院天数均低于常规治疗组,组间比较差异有统计学意义(P<0.05)。经Pearson检验分析,炎性因子CRP、IL-6、TNF-α与患者的急性加重发生次数、住院次数、住院天数呈正相关(P<0.05)。结论健康行为管理能够降低COPD患者体内的炎性因子水平,并可降低患者急性加重的发生次数,且COPD患者严重因子水平与急性加重呈正相关性,可为COPD病情的进展、疗效评估提供参考依据。Objective To investigate the effects of health behavior management on inflammation levels in patients with chronic obstructive pulmonary disease(COPD)and its correlation with acute exacerbation of COPD.Methods A total of 120 patients with COPD who were admitted and treated in our hospital from January 2015 to January 2017 were enrolled in the study,who were divided into health management group(n=60)and routine treatment group(n=60)according to random number table method.The patients in both groups received routine treatment.On the basis of this,the patients in health management group were given health behavior management intervention.Another 50 healthy volunteers who underwent physical examination in our hospital at the same period were enrolled as control group.The levels of inflammatory factors in the three groups were detected and compared,and the frequency of acute exacerbation of COPD during treatment was observed and compared between health management group and conventional treatment group.Moreover the correlation between the levels of inflammatory factors and the frequency of acute exacerbation of COPD patients was analysed by means of Pearson test.Results After treatment,the levels of inflammatory factors including C reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α)in health management group and conventional treatment group were significantly higher than those in control group,moreover the indexes in health management group were significantly lower than those in routine treatment group(P<0.05).The frequency of acute exacerbation of COPD,the hospitalization time and the average length of hospitalization in health management group were significantly lower than those in routine treatment group(P<0.05).Pearson test showed that the inflammatory factors CRP,IL-6 and TNF-αwere positively correlated with the number of times of acute exacerbation of COPD,hospitalization time and hospitalization days(P<0.05).Conclusion Health behavior management can decrease the levels of inflammatory f

关 键 词：慢性阻塞性肺疾病 急性加重 健康行为管理 炎性因子 相关性分析 C-反应蛋白 白介素-6 肿瘤坏死因子-Α 

分 类 号：R971.1[医药卫生—药品]