3D打印技术用于不规则骨缺损的重建与修复  

3D printing technology for reconstruction and repair of irregular-shaped bone defects

作　　者：吴华初 张洪波 于凤宾 岑莲[1] WU Huachu;ZHANG Hongbo;YU Fengbin;CEN Lian(East China University of Science and Technology,School of Chemical Engineering,Shanghai 200237,China;Huzhou 98 Hospital,Huzhou 313000,Zhejiang,China)

机构地区：[1]华东理工大学,化工学院,上海200237 [2]湖州市98医院,浙江湖州313000

出　　处：《精细化工》2020年第8期1653-1656,共4页Fine Chemicals

摘　　要：为研究3D打印技术对不规则形状骨缺损模型的重建程度及3D打印的可降解生物材料对脊椎骨缺损在12周内的修复效果,随机选取1名病人,用电子计算机断层扫描(CT)数据构建出不规则的三维脊柱缺损模型,选用聚己内酯(PCL)作为支架材料,运用3D打印技术打印出高度符合该病人骨缺损部位的人工骨支架。同时建立1个简单的兔子脊椎缺损模型,以聚乳酸-羟基乙酸共聚物(PLGA)为支架材料,运用3D打印技术打印缺损尺寸的支架移植兔子体内,术后观察3个月,将兔子处死取出缺损部位,制作切片进行苏木素和伊红(H&E)染色,染色结果表明缺损部位修复良好。To study the reconstruction degree of irregular-shaped bone defect models by 3 D printing technology and the effect of 3 D printed degradable biomaterials on the repair of vertebral bone defectsin twelve weeks,biodegradable biomaterials,polycaprolactone(PCL)was used as printing ink to print scaffold material for repair.An irregular 3 D spine defect model was constructed using computed tomography(CT)data from a randomly chosen patient.An artificial bone scaffold was printed out by 3 D printing technology,which was highly consistent with the bone defect of the patient.At the same time,a simple model of spinal defect in rabbit was established,and a defect-sized stent was printed by 3 D printing technology using poly(lactic-co-glycolic acid)(PLGA)as scaffold material and then transplanted into the rabbit.The defect was removed from the rabbit after 3 months.The sections of the defect area were made for Hematoxylin and Eosin(H&E)staining.The results indicated that 3 D printed bone scaffold was repaired well.

关 键 词：3D打印技术 支架 骨组织工程 组织学检测 生物工程 

分 类 号：R318.08[医药卫生—生物医学工程]