冻干重组人脑利钠肽联合替罗非班对急性心肌梗死患者趋化素、半凝乳素-3水平的影响  

Effect of lyophilized recombinant human brain natriuretic peptide combined with tirofiban on the levels of chemorin and Gal-3 in patients with acute myocardial infarction

作　　者：翟向伟[1] 高宏勇 王燕妮[3] 白玲[3] 雷新军[3] ZHAI Xiangwei;GAO Hongyong;WANG Yanni(Baoji People’s Hospital of Shaanxi Provence,Baoji 721000)

机构地区：[1]陕西省宝鸡市人民医院,宝鸡721000 [2]西安国际医学中心医院,西安710100 [3]西安交通大学第一附属医院,西安710061

出　　处：《陕西医学杂志》2020年第8期995-998,共4页Shaanxi Medical Journal

基　　金：陕西省科技惠民计划项目(2016HM-04)。

摘　　要：目的:探讨冻干重组人脑利钠肽联合替罗非班对急性心肌梗塞患者趋化素(Chemerin)、半凝乳素-3(Gal-3)水平的影响。方法:选取128例急性心肌梗塞患者为研究对象,依据双色球法随机分为对照组和联合组,各64例。其中对照组患者给予替罗非班治疗,联合组患者给予冻干重组人脑利钠肽联合替罗非班治疗。比较两组患者治疗后的临床疗效和不良反应发生情况,治疗前后的血管内皮功能、血清Chemerin和Gal-3水平及心功能指标。结果:对照组患者治疗后的总有效率为81.25%,联合组患者治疗后的总有效率为98.44%,两组比较的差异具有统计学意义(χ^2=10.360,P<0.05)。与对照组相比,联合组患者治疗后NO水平显著升高;ET-1水平显著低降低,组间比较差异有统计学意义(t=9.311,9.346,P<0.05)。联合组患者治疗后Chemerin和Gal-3水平低于对照组,两组比较差异有统计学意义(t=16.906,13.970,P<0.05)。联合组患者治疗后LVEF水平高于对照组,LVEDD水平低于对照组,两组比较差异有统计学意义(t=11.233,7.130,P<0.05)。两组患者治疗后SV和CI比较差异无统计学意义(t=0.772,0.595,P>0.05)。联合组和对照组患者治疗过程中不良反应发生率分别为3.13%和7.81%,两组比较差异无统计学意义(χ^2=1.360,P>0.05)。结论:应用冻干重组人脑利钠肽联合替罗非班治疗急性心肌梗塞患者临床效果显著,可显著改善患者的血管内皮功能和心功能,降低Chemerin和Gal-3水平,且安全性较高。Objective:To investigate the effect of lyophilized recombinant human brain natriuretic peptide(rhBNP)combined with tirofiban on the levels of chemerin and Gal-3 in patients with acute myocardial infarction.Methods:128 patients with acute myocardial infarction were randomly divided into control group and combined group,with 64 cases in each group.The control group was treated with tirofiban,and the combined group was treated with rhBNP and tirofiban.The clinical effect and adverse reactions of the two groups after treatment were compared and analyzed.The vascular endothelial function,the levels of serum chemerin and Gal-3,and the indexes of cardiac function before and after treatment were analyzed.Results:After treatment,the total effective rate of the combined group was 98.44%,which was significantly higher than that of the control group(81.25%)(χ^2=10.360,P<0.05);the level of NO in thecombined group was significantly higher than that in the control group,and the level of ET-1 was significantly lower than that in the control group(t=9.311,9.346,P<0.05);the levels of chemorin and Gal-3 in the combined group were significantly lower than those in the control group(t=16.906,13.970,P<0.05);the LVEF in the combined group was significantly higher than that in the control group,and the LVEDD was significantly lower than that in the control group(t=11.233,7.130,P<0.05);there was no significant difference in SV and CI between the two groups(t=0.772,0.595,P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ^2=1.360,P>0.05).Conclusion:The clinical effect of rhBNP combined with tirofiban in the treatment of acute myocardial infarction is significant.It can significantly improve the vascular endothelial function and cardiac function of patients,reduce the levels of chemorin and Gal-3,and has high safety.

关 键 词：急性心肌梗死 治疗 冻干重组人脑利钠肽 替罗非班 趋化素 半凝乳素-3 

分 类 号：R541.4[医药卫生—心血管疾病]