铜催化的苯并恶唑、五氟苯与O-苯甲酰羟胺的C—H键胺化反应  

Copper-catalyzed C—H Amination of Benzoxazole and Pentafluorobenzene with O-Benzoyl Hydroxylamines

作　　者：洪建权 杨宇鹏 霍连光 刘洋 郑昌戈 HONG Jian-quan;YANG Yu-peng;HUO Lian-guang;LIU Yang;ZHENG Chang-ge(School of Chemistry and Materials Engineering, Jiangnan University, Wuxi 214122, China)

机构地区：[1]江南大学化学与材料工程学院,江苏无锡214122

出　　处：《合成化学》2020年第8期672-680,共9页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21562041)。

摘　　要：以四氢呋喃为溶剂,在碘化亚铜催化下,苯并恶唑和五氟苯等缺电子芳烃体系与O-苯甲酰羟胺发生C—H键亲电胺化反应,分别以42%~92%和20%~84%的收率合成了多种2-氨基苯并恶唑和五氟苯胺衍生物,其结构经1H NMR和13C NMR表征。Efficient electrophilic amination of electron-deficient arenes has been demonstrated.In the presence of CuI/t-BuOLi,benzoxazole and pentafluorobenzene reacted with O-benzoyl hydroxylamines to afford various 2-aminobenzoxazole and pentafluoroanilines derivatives in 42%~92%and 20%~84%yields,respectively.All of the compounds were characterized by 1H NMR and 13C NMR.

关 键 词：胺化 铜催化剂 苯并恶唑 五氟苯 O-苯甲酰羟胺 合成 

分 类 号：O625.632[理学—有机化学] O621.3[理学—化学]