广西某有色金属矿区血镉与人群肝功能的相关性研究  

Association of cadmium pollution with liver function of population in mineral polluted areas of Guangxi

作　　者：曲英莉[1] 蔡嘉旖 陈曦[1] 郑磊[1] 黄林[2] 杨家信 叶秀[1] 王强[1] 司国爱 曹兆进[1] Qu Yingli;Cai Jiayi;Chen Xi;Zheng Lei;Huang Lin;Yang Jiaxin;Ye Xiu;Wang Qiang;Si Guoai;Cao Zhaojin(National Institute of Environmental Health,Chinese Center For Disease Control And Prevention,Beijing 100050,China;Guangxi Center for Disease Prevention and Control,Nanning 530028,China;Jinchengjiang District Center for Disease Prevention and Control of Hechi City of Guangxi Province,Hechi 547000,China)

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100050 [2]广西壮族自治区疾病预防控制中心,南宁530028 [3]广西壮族自治区河池市金城江区疾病预防控制中心,547000

出　　处：《中华预防医学杂志》2020年第8期839-843,共5页Chinese Journal of Preventive Medicine

基　　金：国家环保公益性行业科研专项经费(201309049)。

摘　　要：目的研究广西某有色金属矿区血镉暴露与成年居民肝功能的相关性。方法于2013—2014年,以广西某有色金属矿业污染区的5个重金属污染村作为研究现场,招募到310名符合标准的18岁及以上居民为研究对象。通过问卷调查、体格检查和实验室检测的方法,获取对象一般人口学特征、血镉水平及肝功能指标[总胆红素(TBIL)、谷草转氨酶(AST)、谷丙转氨酶(ALT)及γ-谷氨酰胺转移酶(GGT)]等信息。根据血镉水平四分位数,将研究对象分为Q1~Q4四组(以Q1组为参照组),采用多因素非条件logistic回归模型分析各功能指标与血镉水平之间的关联。结果研究对象的年龄为(49.2±15.4)岁;男性为112名(36.1%);血镉水平G(95%CI)为3.72(3.43~4.02)μg/L;肝效应指标TBIL、AST、ALT及GGT的异常率分别为17.4%(54例)、19.7%(61例)、10.7%(33例)及11.9%(37例)。调整年龄、性别、BMI、吸烟、饮酒、总胆固醇血症、高甘油三酯血症等因素后,与血镉水平Q1组对象相比,Q4组对象AST发生异常的风险较大[OR(95%CI)值为2.92(1.07~7.98)]。结论该有色金属矿区血镉水平高于我国一般人群参考值;镉暴露与AST异常有关联。Objective To investigate the association of cadmium exposure with liver function among adults in a non-ferrous metal mining area in Guangxi.Methods A total of 310 residents aged 18 and above were recruited from 5 heavy metals polluted villages in a non-ferrous metal mining area in Guangxi from 2013 to 2014.The general demographic characteristics,blood cadmium levels and indicators of liver function index[Total bilirubin(TBIL),Glutamic oxaloacetic transaminase(AST),Alanine transaminase(ALT)and Glutamine transaminase(GGT)]were obtained by using questionnaire,physical examination and laboratory test.The blood cadmium levels were divided into quartiles as Q1-Q4 groups(using Q1 group as the reference).Multivariate logistic regression model was used to analyze the correlation between the blood cadmium level and functional liver index.Results The age of subjects was(49.2±15.4)years,and 112(36.1%)subjects were male residents.The prevalence of abnormal rates of TBIL,AST,ALT and GGT were 17.4%(54),19.7%(61),10.7%(33)and 11.9%(37),respectively.The geometric mean value of cadmium levels in adults was 3.72(95%CI:3.43-4.02)μg/L.After adjusting for age,gender,body mass index(BMI),smoking,drinking,total cholesterol,hypertriglyceridemia and other factors,the risk of abnormal AST index in the highest concentration of blood cadmium group(Q4)was higher than that in the lowest concentration of blood cadmium group(Q1)(OR=2.92,95%CI:1.07-7.98).Conclusion The level of blood cadmium exposure is higher than the reference value of general population in China,and the elevated cadmium exposure is related to the increasing risk of AST abnormality.

关 键 词：镉 肝功能 内暴露 成人 横断面研究 

分 类 号：R195[医药卫生—卫生统计学]