丹参类制剂及丹参活性成分改善脑循环作用机制的研究进展  

Research progress on pharmacology and pharmacological mechanism of improving cerebral circulation function by main components and preparation of Salvia miltiorrhiza

作　　者：孙环宇 许晴 张燕欣 李德坤[1,2] 李洪英 林梅 胡靖 鞠爱春[1,2] SUN Huanyu;XU Qing;ZHANG Yanxin;LI Dekun;LI Hongying;LIN Mei;HU Jing;JU Aichun(Tianjin Tasly Pride Pharmaceutical Co.,Ltd.,Tianjin 300410,China;Tianjin Key Laboratory of Safety Evaluation Enterprise of Traditional Chinese Medicine Injections,Tianjin 300410,China;Hebei College of Traditional Chinese Medicine,Shijiazhuang 050200,China)

机构地区：[1]天津天士力之骄药业有限公司,天津300410 [2]天津市中药注射剂安全性评价企业重点实验室,天津300410 [3]河北中医学院,河北石家庄050200

出　　处：《药物评价研究》2020年第8期1496-1500,共5页Drug Evaluation Research

基　　金：天津市科技重大专项与工程(18ZXXYSY00120)。

摘　　要：近年来,随着脑血管病的发病率不断升高,其相关病症已经严重的影响了患者的生活质量。研究发现丹参类制剂及丹参活性成分具有明显的改善脑循环作用,主要从改善脑部微循环、改善脑侧支循环以及促进侧支血管的新生3个方面归纳总结了丹参类制剂及丹参活性成分改善脑循环的药理作用及作用机制,旨在为丹参类制剂改善患者脑循环的应用提供理论依据。In recent years,with the increasing incidence of cerebrovascular diseases,the related diseases have seriously affected the quality of patients,life.Studies have been found that the preparations and active ingredients of Salvia miltiorrhiza have obvious effects on improving brain circulation of patients.This review summarizes the pharmacology and pharmacological mechanism of preparation and active components of Salvia miltiorrhiza improving cerebral circulation from three aspects,improving cerebral microcirculation,improving cerebral collateral circulation and promoting neogenesis of cerebral collateral vessels.The purpose of this review is to provide theoretical basis for clinical application of Salvia miltiorrhiza preparation in improving cerebral circulation of patients.

关 键 词：脑循环 丹参 丹参类制剂 活性成分 药理作用 药理机制 

分 类 号：R285.6[医药卫生—中药学] R286.1[医药卫生—中医学]