Molecular actions of NLR immune receptors in plants and animals  

作　　者：Jizong Wang Jijie Chai 

机构地区：[1]Beijing Advanced Innovation Center for Structural Biology,Tsinghua-Peking Joint Center for Life Sciences,Center for Plant Biology,School of Life Sciences,Tsinghua University,Beijing 100084,China [2]Max-Planck Institute for Plant Breeding Research,Cologne 50829,Germany [3]Institute of Biochemistry,University of Cologne,Cologne 50674,Germany

出　　处：《Science China(Life Sciences)》2020年第9期1303-1316,共14页中国科学（生命科学英文版）

基　　金：supported by the Alexander von Humboldt Foundation(Humboldt Professorship of Jijie Chai)。

摘　　要：NLRs constitute intracellular immune receptors in both plants and animals. Direct or indirect ligand recognition results in formation of oligomeric NLR complexes to mediate immune signaling. Over the past 20 years, rapid progress has been made in our understanding of NLR signaling. Structural and biochemical studies provide insight into molecular basis of autoinhibition,ligand recognition, and resistosome/inflammasome formation of several NLRs. In this review, we summarize these studies focusing on the structural aspect of NLRs. We also discuss the analogies and differences between plant and animal NLRs in their mechanisms of action and how the available knowledge may shed light on the signaling mechanisms of other NLRs.

关 键 词：NLR immune receptor autoihibition pathogen perception resistosome/inflammasome molecular mechanism 

分 类 号：S432.2[农业科学—植物病理学] S852.4[农业科学—农业昆虫与害虫防治]