Transposon-based screen identifies a XRE family regulator crucial for candicidin biosynthesis in Streptomyces albus J1074  

作　　者：Jun Tian Leixin Ye Yuling Yang Yalin Zhang Changhua Hu Guojian Liao 

机构地区：[1]Institute of Modern Biopharmaceuticals,College of Pharmaceutical Sciences,Southwest University,Chongqing 400715,China

出　　处：《Science China(Life Sciences)》2020年第9期1421-1424,共4页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(31670050,31100069);the Fundamental Research Funds for the Central Universities(XDJK2017B011)。

摘　　要：Dear Editor,Polyene macrolides are a group of natural products with potent antifungal activity (Caffrey et al., 2016). Candicidin/FR-008, a potent broad-spectrum anti-fungal agent, is produced by several Streptomycetes, including Streptomycetes sp. strain FR-008 (Chen et al., 2003), S. griseus 3570(Campelo and Gil, 2002) and S. albus J1074 (Olano et al.,2014). Due to its medical importance, considerable effort has been applied to elucidate its biosynthetic pathway and identify key regulatory genes (Chen et al., 2003;Zhang et al.,2015).

关 键 词：agent cidin identif 

分 类 号：Q935[生物学—微生物学]