脑苷肌肽联合亚低温治疗创伤性颅脑损伤的早中期结果及生存质量分析  

The early-middle outcomes and analysis of life quality of traumatic brain injury patients with cattle encephalon glycoside and mild hypothermia therapy combined treatment

作　　者：孟彦丽[1] 董自平[1] 宋海红[2] 李哲敏 胡洁 宋建亭 李滨 MENG Yanli;DONG Ziping;SONG Haihong;LI Zhemin;HU Jie;SONG Jianting;LI Bin(Departemnt of Emergency Medicine,General Hospital of Huabei Oilfield,062552 China)

机构地区：[1]河北省任丘市华北石油管理局总医院急诊医学科,河北任丘062552 [2]河北省任丘市华北石油管理局总医院全科医学科,河北任丘062552 [3]河北省任丘市华北石油管理局总医院功能检查科,河北任丘062552 [4]河北省任丘市华北石油管理局医院神经外科,河北任丘062552

出　　处：《中国急救复苏与灾害医学杂志》2020年第8期940-943,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：河北省卫生健康委员会医学会科技计划项目(编号:20191170)。

摘　　要：目的评价脑苷肌肽联合亚低温治疗对创伤性颅脑损伤患者的院内早期、中期结果,研究不同治疗策略对创伤性颅脑损伤患者出院后生存质量的影响。方法回顾性分析258例创伤性颅脑损伤患者病例,根据药物使用情况将患者分为脑苷肌肽+亚低温治疗组(治疗组)和亚低温治疗组(对照组)。两组患者均采取降颅压、抗感染、保护脑细胞、解痉挛等常规治疗措施。根据患者病情严重程度,对经过外科手术的患者和采取内科保守治疗的患者,进行亚组分析。对所有出院后患者进行随访,评价患者早中期死亡率和生存质量。结果治疗组患者与对照组患者在院内死亡率和早中期生存分析中未产生显著性差异。亚组分析中,手术治疗组和手术对照组患者的生存分析与总体患者一致。治疗组患者在住院时间和GCS评分提升上,显著短于并优于对照组患者。手术患者中,治疗组患者在ICU时间,机械通气时间和住院时间上均显著短于对照组。院外生存质量上,治疗组患者在早期生存质量评分显著高于对照组,之后并未产生统计学差异。结论对于创伤性颅脑损伤的患者,脑苷肌肽联合亚低温的治疗方案可以缩短患者住院时间,提高患者院外早期生存质量。对于创伤性颅脑损伤的手术患者,治疗中采用脑苷肌肽联合亚低温治疗的方案可以缩短患者术后的恢复时间。Objective To investigate the early-middle outcomes and analysis of life quality of traumatic brain injury patients with cattle encephalon glycoside and mild hypothermia therapy combined treatment.Methods 258TBIpatients’clinical data were collected to retrospectively analyze.All patients were divided into two groups based on the therapy,which were the cattle encephalon glycoside group and the mild hypothermia therapy and cattle encephalon glycoside combined group.Basic measures such as reducing intracranial pressure, anti-infection, prolecting brain nerve cells and reducing spasmolysis were taken into all the patients.Based on the states of patients,subgroup analysis to patients with surgery and only drug treatment.Results There was no significant difference between in the treatment group and control group on hospital mortality and early-middle term of mortality. In the subgroup analysis, the hospital and early-middle term of mortality present the same trend with the overall analysis.While,about hospital stay,and increasing GCS score,the patients in the treat group showed a significant better result compared to the control group.To the patients received surgeries,the patients in treat group were observed significant shorter than patients in control group on the ICU stay,mechanical ventilation time and hospital stay.About the life quality scoring,6-month life quality were observed a significant difference between two groups which the treat group patients are better,and after that no differences were presented.Conclusion ToT BIpatients,the mild hypothermia and cattle encephalon glycoside combined therapy can reduce the patients hospital stay and improve early-term of lifequality.To the surgical patients,this therapy can efficiently shorten the recovery time of patients in hospital.

关 键 词：亚低温 脑苷肌肽 颅脑损伤 生存质量 

分 类 号：R459.7[医药卫生—急诊医学]