Zinc-ZIP8-MTF1信号通路调控骨性关节炎发生、发展及中医药作用机制的研究进展  

Research progress on Zinc-ZIP8-MTF1 signal pathway in the pathogenesis of osteoarthritis and the mechanism of traditional Chinese medicine

作　　者：熊振飞[1] 汤样华[1] 李金龙[2,3] 唐德志[2,3] XIONG Zhenfei;TANG Yanghua;LI Jinlong;TANG Dezhi(Department of Orthopedics,Xiaoshan District Hospital of Traditional Chinese Medicine,Hangzhou 311201,Zhejiang China;Department of Orthopedics,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Institute of Spinal Diseases,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]浙江省杭州市萧山区中医院骨伤科,浙江杭州311201 [2]上海中医药大学附属龙华医院骨科,上海200032 [3]上海中医药大学脊柱病研究所,上海200032

出　　处：《上海中医药杂志》2020年第8期89-93,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81603636);浙江省杭州市萧山区科技计划项目(2017308)。

摘　　要：综述锌离子-锌离子转运蛋白8-金属调节转录因子1(Zinc-ZIP8-MTF1)信号通路调控骨性关节炎发生发展及中医药作用机制的研究进展。Zn^2+稳态、锌转运蛋白以及锌离子依赖性转录因子与软骨损伤密切相关,Zinc-ZIP8-MTF1信号通路可调控骨性关节炎的发生、发展。目前中医药领域的相关研究局限于对Zn^2+水平的调控,未涉及对ZIP8和MTF1的影响,因此研究中医药对Zinc-ZIP8-MTF1信号通路的影响对治疗骨性关节炎有重要意义。The progress was reviewed on Zinc-ZIP8-MTF1 signal pathway in the pathogenesis of osteoarthritis and the mechanism of traditional Chinese medicine.There was an association of zinc(Zn^2+)homeostasis,Zn^2+transporters,and Zn^2+-dependent transcription factors with cartilage injury.Futhermore,the Zinc-ZIP8-MTF1 signal pathway could regulate the occurrence and development of osteoarthritis.Until now,the research of traditional Chinese medicine in this field is limited to the regulation of Zn^2+level,and is unknown about the influence on ZIP8 and MTF1.Therefore,it has important role in the treatment for OA to study the effect of traditional Chinese medicine on zinc-zip8-mtf1 signal pathway.

关 键 词：骨性关节炎 Zinc-ZIP8-MTF1信号通路 基质金属蛋白酶 中医药疗法 综述 

分 类 号：R274.9[医药卫生—中西医结合]